【摘要】：目的比較流腦多糖疫苗和流腦結(jié)合疫苗的安全性。方法選擇6~18月齡和36~38月齡的常住健康人群,分別隨機分為多糖疫苗組和結(jié)合疫苗組接種相應(yīng)疫苗。6~18月齡兒童間隔3個月接種同種疫苗第2劑,接種后進行30 min即時反應(yīng)和72 h反應(yīng)的隨訪觀察。結(jié)果不論1劑或2劑接種,A群流腦多糖疫苗、A+C群流腦多糖疫苗和A+C群流腦結(jié)合疫苗均表現(xiàn)出良好的耐受性;總體不良反應(yīng)發(fā)生率為3.44%,均為輕度。各組間差異無統(tǒng)計學意義(χ2=0.80,P=0.67;χ2=0.79,P=0.67;χ2=3.13,P=0.21)。結(jié)論流腦多糖疫苗和流腦結(jié)合疫苗在兒童中均表現(xiàn)出良好的安全性,建議將流腦結(jié)合疫苗納入國家免疫規(guī)劃,提高預防效果并擴大菌群覆蓋范圍。
[Abstract]:Objective to compare the safety of cerebrospinal polysaccharide vaccine and cerebrospinal meningitis combined vaccine. Methods healthy people aged 6-18 months and 36-38 months old were randomly divided into two groups: the vaccine group and the combined vaccine group. The second dose of the same vaccine was given to the children aged 6 months and 18 months at an interval of 3 months, and the children aged 6 months and 18 months were randomly divided into two groups: the polysaccharide vaccine group and the combined vaccine group. All patients were followed up for 30 min immediate response and 72 h response. Results both group A cerebrospinal polysaccharide vaccine (, A C) and group A / C combined vaccine showed good tolerance, and the overall adverse reaction rate was 3.44%, all of which were mild. There was no significant difference among the three groups (蠂 2 = 0.80, P = 0.67; 蠂 2 = 0.79, P = 0.67; 蠂 2 = 3.13, P = 0.21). Conclusion both cerebrospinal polysaccharide vaccine and cerebrospinal fluid combined vaccine are safe in children. It is suggested that the vaccine should be incorporated into the national immunization program to improve the preventive effect and expand the coverage of the flora.
【作者單位】： 南昌市疾病預防控制中心;
【分類號】：R392-33

【相似文獻】

相關(guān)期刊論文 前10條

1 ;肺炎球菌多糖疫苗的功效——對當前推薦的評價[J];中國計劃免疫;1997年05期

2 盧振花;1例接種23價肺炎多糖疫苗引起的過敏反應(yīng)[J];現(xiàn)代預防醫(yī)學;2004年06期

3 郝鳳;姜梅;曲淑娜;;接種A群腦膜炎多糖疫苗致多形紅斑1例[J];預防醫(yī)學論壇;2008年08期

4 吳海英;接種A群腦膜炎多糖疫苗致過敏反應(yīng)一例[J];安徽預防醫(yī)學雜志;2000年02期

5 慕艷紅;王晶;趙志強;朱莉萍;;離子色譜在多糖疫苗及多糖蛋白結(jié)合疫苗質(zhì)量控制中的應(yīng)用[J];微生物學免疫學進展;2012年06期

6 孟曉慧;劉紅菊;何云莉;;23價肺炎多糖疫苗疫苗接種率的調(diào)查分析[J];中國醫(yī)藥指南;2013年19期

7 何莓;王健;王惟信;張宏;華羚;;流腦多糖疫苗在出境人群中的應(yīng)用[J];中國國境衛(wèi)生檢疫雜志;2012年02期

8 王新華,劉季平;一起接種流腦多糖疫苗偶合流感暴發(fā)分析[J];預防醫(yī)學文獻信息;2000年04期

9 嚴惠琴;以乳糖為溶劑增進凍干腦膜炎球菌多糖疫苗的穩(wěn)定性[J];國外醫(yī)學參考資料.流行病學傳染病學分冊;1978年01期

10 李永紅;;傷寒Vi多糖疫苗在我國的研究與應(yīng)用現(xiàn)狀[J];實用預防醫(yī)學;2007年03期

相關(guān)重要報紙文章 前2條

1 言誠;首個人工合成多糖疫苗問世[N];醫(yī)藥經(jīng)濟報;2004年

2 記者 吳正懿;智飛生物AC多糖疫苗獲藥品注冊批件[N];上海證券報;2011年

，

本文編號：2450628