【摘要】：NOD蛋白包括NOD1和NOD2,兩者識別細菌肽聚糖的片段,誘導促炎和抗菌反應。在本篇綜述中,我們介紹近年來NOD蛋白的研究進展,包括激活的方式,信號途徑的調節(jié),在細胞中的定位以及在免疫防御過程中發(fā)揮的作用。洞悉NOD蛋白誘導的信號通路有助于了解相關疾病的致病機理,為疾病的治療提供新的視角。
[Abstract]:NOD proteins, including NOD1 and NOD2, recognize fragments of bacterial peptidoglycan and induce inflammatory and antimicrobial reactions. In this review, we review the recent advances in the study of NOD proteins, including the way of activation, regulation of signal pathways, localization in cells and role in immune defense. Understanding the signal pathway induced by NOD protein is helpful to understand the pathogenesis of related diseases and provide a new perspective for the treatment of diseases.
【作者單位】： 中國科學院生物物理研究所中科院感染與免疫重點實驗室;
【分類號】：R392
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本文編號：2368217