【摘要】：細(xì)胞自噬是真核細(xì)胞一種進(jìn)化上保守,周轉(zhuǎn)細(xì)胞內(nèi)物質(zhì)的一個重要生理過程。細(xì)胞自噬既能清除胞質(zhì)內(nèi)異常的蛋白質(zhì)和細(xì)胞器,又能在特定條件下維持細(xì)胞的生存,具有廣泛的生理功能。造血干細(xì)胞是血液系統(tǒng)中一類能維持靜息狀態(tài)、自我更新和具有多向分化潛能的特殊細(xì)胞。近年來的研究不斷揭示細(xì)胞自噬在造血干細(xì)胞的特性維持和調(diào)節(jié)中發(fā)揮著重要作用。現(xiàn)就細(xì)胞自噬在造血干細(xì)胞特性調(diào)節(jié)中的研究現(xiàn)狀進(jìn)行概述。
[Abstract]:Autophagy is an important physiological process of eukaryotic cells. Autophagy not only clears the abnormal proteins and organelles in the cytoplasm, but also maintains the survival of the cells under certain conditions, and has a wide range of physiological functions. Hematopoietic stem cells (HSCs) are special cells in the blood system which can maintain resting state, self-renewal and multi-differentiation potential. Recent studies have revealed that autophagy plays an important role in the maintenance and regulation of hematopoietic stem cells. In this paper, the current research status of autophagy in the regulation of hematopoietic stem cell characteristics is reviewed.
【作者單位】： 第三軍醫(yī)大學(xué)熱帶醫(yī)學(xué)研究所;第三軍醫(yī)大學(xué)西南醫(yī)院血液病中心;
【基金】：國家自然科學(xué)基金面上項目(81170471,31371913) 重慶市科委基金重點項目(csct2013jj B0190)
【分類號】：R329.2

【共引文獻(xiàn)】

相關(guān)期刊論文 前8條

1 Massimo Marenzana;Timothy R.Arnett;;The Key Role of the Blood Supply to Bone[J];Bone Research;2013年03期

2 夏耘秋;鄒琳;符州;;間充質(zhì)干細(xì)胞治療急性肺損傷和急性呼吸窘迫綜合征的機(jī)制[J];兒科藥學(xué)雜志;2015年06期

3 LIU YiMing;ZHANG BoWen;ZHANG Jing;WANG SiHan;YAO HaiLei;HE LiJuan;CHEN Lin;YUE Wen;LI YanHua;PEI XueTao;;CAPE promotes the expansion of human umbilical cord blood-derived hematopoietic stem and progenitor cells in vitro[J];Science China(Life Sciences);2014年02期

4 景鵬偉;胡文煦;宋小英;張巖巖;賈道勇;張夢思;夏婕妤;李靜;王亞平;王璐;;衰老大鼠模型骨髓基質(zhì)細(xì)胞的生物學(xué)特點[J];解剖學(xué)報;2015年01期

5 黃鑫;高雪靜;王淵;張瑩;唐莎;鄒麗云;王莉;張靜波;;分子伴侶性自噬參與LAMP-2抗體誘導(dǎo)中性粒細(xì)胞胞外捕網(wǎng)形成[J];免疫學(xué)雜志;2015年03期

6 DONG Liang;HAO HaoJie;HAN WeiDong;FU XiaoBing;;The role of the microenvironment on the fate of adult stem cells[J];Science China(Life Sciences);2015年07期

7 喻楊;王喻義;王乙欽;蔣明;;腫瘤干細(xì)胞與腫瘤微環(huán)境相互作用的研究進(jìn)展[J];華西醫(yī)學(xué);2015年09期

8 崔玉琳;齊，

本文編號：2229534