本文選題：細(xì)胞焦亡 + GSDMD　； 參考：《醫(yī)學(xué)研究生學(xué)報》2017年06期

【摘要】：細(xì)胞焦亡是新近發(fā)現(xiàn)的一種程序性細(xì)胞死亡形式,與感染性疾病、自發(fā)炎癥性疾病和自身免疫性疾病休戚相關(guān),Gasdermin-D(GSDMD)是細(xì)胞焦亡的效應(yīng)分子。炎性半胱天冬酶(caspases)通過裂解GSDMD,打破其結(jié)構(gòu)自抑制,激活GSDMD的打孔活性。GSDMD的活性形式GSDMD-N端結(jié)構(gòu)域在細(xì)胞膜上聚合形成一個中空的環(huán)狀低聚物,形成孔道。細(xì)胞焦亡與程序性細(xì)胞壞死相似,兩者均能在細(xì)胞膜上形成孔道。文章就細(xì)胞焦亡的研究進(jìn)展、GSDMD參與細(xì)胞焦亡的分子機(jī)制、細(xì)胞焦亡與程序性細(xì)胞死亡的辨別及與細(xì)胞焦亡相關(guān)的疾病進(jìn)行綜述。
[Abstract]:Apoptosis is a newly discovered programmed cell death form. It is closely related to infectious diseases, spontaneous inflammatory diseases and autoimmune diseases. Gasdermin-D GSDMDD) is the effector molecule of cellular pyrolysis. Inflammatory cysteine aspergase (caspaseses) cleavage GSDMDs, break down its structural self-inhibition, and activate the perforation activity of GSDMD. The active form of GSDMD-N terminal domain of GSDMD polymerizes on the cell membrane to form a hollow ring oligomer, forming a pore channel. Pyrolysis is similar to programmed cell necrosis, both of which can form pores on the cell membrane. In this paper, the molecular mechanism of GSDMD involved in cell pyrolysis, the discrimination between cellular pyrolysis and programmed cell death, and the diseases related to cell pyrolysis are reviewed.
【作者單位】： 廣東醫(yī)科大學(xué);廣東醫(yī)科大學(xué)附屬醫(yī)院心血管內(nèi)科;
【基金】：國家自然科學(xué)基金(81270262)
【分類號】：R363
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本文編號：1927428