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  本文選題：多維疾病性狀　切入點：結(jié)構(gòu)信息　出處：《東北師范大學(xué)》2012年碩士論文

【摘要】：在復(fù)雜疾病基因定位研究中，人們會獲得許多與之相關(guān)的表現(xiàn)性狀，我們稱之為多維疾病性狀。它們可能由相同的遺傳變異導(dǎo)致，也可能受不同的遺傳變異控制。雖然基于多維性狀的關(guān)聯(lián)分析方法較復(fù)雜，基于單個疾病性狀的關(guān)聯(lián)分析方法較為簡單，但是在某些情況下，單個疾病性狀的關(guān)聯(lián)分析方法會降低檢驗的功效。已經(jīng)有人通過模擬研究指出在什么情況下采取多維疾病性狀的關(guān)聯(lián)分析功效性要優(yōu)于單個疾病性狀的關(guān)聯(lián)分析。但是以往進行多維性狀關(guān)聯(lián)分析時，，雖然考慮到了性狀之間的關(guān)系，卻并沒有考慮過性狀間的結(jié)構(gòu)信息，即性狀間的方向性對分析效果的影響。本文我們通過考慮致病位點與性狀間的多種關(guān)系結(jié)構(gòu)圖來產(chǎn)生模擬數(shù)據(jù)，通過模擬研究來分析性狀間的結(jié)構(gòu)信息對遺傳關(guān)聯(lián)分析的影響。模擬結(jié)果顯示，當(dāng)基因與性狀間關(guān)聯(lián)性較弱時，考慮性狀間的結(jié)構(gòu)信息優(yōu)勢并不顯著；基因與性狀間關(guān)聯(lián)性越強，其功效性優(yōu)勢越顯著。
[Abstract]:In the study of complex disease gene mapping, people will get a lot of related characters, we call multidimensional traits. They may cause disease by the same genetic variation, genetic variation may also be affected by different control. Although the correlation analysis method of multidimensional complex traits based on correlation analysis method based on single disease traits relatively simple, but in some cases, relevance of single disease traits analysis method will reduce the effectiveness of test has been through simulation studies and points out that adopting correlative multi-dimensional disease traits in what circumstances the association analysis is better than that of single disease traits to analysis efficacy. But previous analysis of multidimensional association, while taking into account the relationship between the traits, but did not consider structural information between characters, effects between traits of direction effect analysis. In this paper we Considering the variety structure of the relationship between characters and pathogenic sites to generate simulated data, through simulation studies to analyze the impact of structural information of the traits of genetic association. The simulation results show that when the relationship between genes and traits is weak, considering the structural information advantage among traits is not significant; the correlation between the genes and traits strong, its efficacy advantage is more significant.

【學(xué)位授予單位】：東北師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R394;R311;O212.1

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