本文關(guān)鍵詞：血脂平膠囊對高血脂模型金黃地鼠血脂水平的影響及機(jī)制研究　出處：《中國藥房》2017年16期 　論文類型：期刊論文

  更多相關(guān)文章： 血脂平膠囊 高血脂 降血脂 作用機(jī)制 金黃地鼠

【摘要】：目的:研究血脂平膠囊對高血脂模型金黃地鼠血脂水平的影響及其可能機(jī)制。方法:將金黃地鼠隨機(jī)分為正常對照組、模型組、阿托伐他汀組(3 mg/kg)、聯(lián)用組(血脂平膠囊1.3 g/kg+阿托伐他汀1.5 mg/kg)和血脂平膠囊低、中、高劑量組(血脂平膠囊1.3、2.6、5.2 g/kg),每組10只。正常對照組地鼠給予普通飼料,其他組地鼠給予高脂飼料建立高血脂模型,2周后同時(shí)ig給予相應(yīng)藥物,正常對照組和模型組地鼠ig等體積的蒸餾水,每日1次,連續(xù)給藥4周。末次給藥后,檢測各組地鼠血脂指標(biāo)[總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、游離脂肪酸(FFA)],肝組織中脂質(zhì)代謝相關(guān)基因(PPAR-α、CYP7A1、ACOX、SREBP-1c、ACC1)m RNA及蛋白表達(dá)。結(jié)果:與正常對照組比較,模型組地鼠血清TC、TG、LDL-C、FFA含量增加,HDL-C含量降低,PPAR-α、CYP7A1、ACOX m RNA及蛋白表達(dá)減弱,SREBP-1c、ACC1 m RNA及蛋白表達(dá)增強(qiáng)(P0.05)。與模型組比較,血脂平膠囊高劑量組、阿托伐他汀組和聯(lián)用組地鼠上述指標(biāo)均明顯改善(血脂平高劑量組HDL-C除外)(P0.05);血脂平膠囊中劑量組地鼠TC、TG、FFA含量和PPAR-α、CYP7A1、ACOX、ACC1 m RNA及CYP7A1、SREBP-1c、ACC1蛋白表達(dá)均明顯改善(P0.05);血脂平膠囊低劑量組地鼠TC、TG含量和PPAR-αm RNA及CYP7A1、SREBP-1c蛋白表達(dá)均明顯改善(P0.05)。結(jié)論:血脂平膠囊具有降血脂作用,其機(jī)制可能與激活PPAR-α和抑制SREBP-1c信號通路有關(guān)。
[Abstract]:Objective: to study the effect and possible mechanism of Shuiping capsule on hyperlipidemia model golden hamster. Methods: Golden hamsters were randomly divided into normal control group and model group. Atorvastatin group (3 mg / kg), combined group (1.3 g / kg Atorvastatin 1.5 mg / kg) and lipids capsule (1.5 mg / kg) were low and medium. 10 rats in each group were given normal diet in normal control group and hyperlipidemia model was established in other groups. After 2 weeks of administration, the rats in the normal control group and the model group were given the same volume of distilled water intravenously, once a day for 4 weeks. After the last administration, the blood lipids were measured in each group. [Total cholesterol (TC), triglyceride (TGN), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), free fatty acid (FFA). Results: the expression of PPAR- 偽 CYP7A1ACOXP-1cACC1m RNA and protein in liver tissue was compared with that in normal control group. In the model group, the serum TCG-TGG LDL-CfFA increased the content of HDL-C and decreased the expression of PPAR- 偽 -CYP7A1ACox m RNA and protein. The expression of ACC1 m RNA and protein in SREBP-1cACC1 m were increased (P 0.05). Compared with the model group, the high dose group of Shuiping capsule. The above indexes were significantly improved in both atorvastatin group and combination group (except for HDL-C with high dose of lipids). In the middle dose group, the content of TCN TGG FFA, PPAR- 偽 CYP7A1ACOX1 m RNA and CYP7A1 + SREBP-1c were measured. The expression of ACC1 protein significantly improved P0.05A; In the low dose group, the content of TG, PPAR- 偽 m RNA and CYP7A1 were measured. The expression of SREBP-1c protein was significantly improved by P0.050.Conclusion: Shuiping capsule has the effect of lowering blood lipids. The mechanism may be related to activation of PPAR- 偽 and inhibition of SREBP-1c signaling pathway.
【作者單位】： 哈爾濱商業(yè)大學(xué)生命科學(xué)與環(huán)境科學(xué)研究中心;中國醫(yī)學(xué)科學(xué)院北京協(xié)和醫(yī)學(xué)院藥用植物研究所;
【分類號】：R285.5;R-332
【正文快照】： *碩士研究生。研究方向:心血管藥理。電話:010-51873226。E-mail:qshen666@126.com由于不良生活方式的影響,在中國,高脂血癥(Hy-perlipidemia,HLP)已成為一種常見的代謝性疾病。該疾病特點(diǎn)為脂代謝異常,包括總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)異常升高和高密度脂

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