本文關(guān)鍵詞：肌細(xì)胞特異性microRNAs對(duì)收縮舒張生物學(xué)效應(yīng)調(diào)控機(jī)制的研究進(jìn)展　出處：《復(fù)旦學(xué)報(bào)(醫(yī)學(xué)版)》2017年03期 　論文類(lèi)型：期刊論文

  更多相關(guān)文章： 肌細(xì)胞特異性microRNAs 平滑肌 骨骼肌 心肌 肌肉收縮舒張機(jī)制

【摘要】：肌細(xì)胞特異性microRNAs(muscle-specific microRNAs,myomiRs)是一類(lèi)特異性表達(dá)在肌組織中的內(nèi)源性非編碼小分子RNA,通過(guò)轉(zhuǎn)錄后水平負(fù)調(diào)控相關(guān)基因的表達(dá),廣泛參與到一系列生物學(xué)過(guò)程中,影響疾病的發(fā)生發(fā)展。肌細(xì)胞相關(guān)疾病(如慢性阻塞性肺炎、肥厚型心肌病等)的發(fā)生、發(fā)展可引起myomiRs及其下游靶基因表達(dá)改變,從而進(jìn)一步影響疾病的發(fā)展、預(yù)后及轉(zhuǎn)歸。本文將綜述miR-1、miR-133、miR-206、miR-208和miR-499等常見(jiàn)myomiRs在橫紋肌和非橫紋肌收縮舒張機(jī)制中的作用,重點(diǎn)關(guān)注myomiRs對(duì)肌細(xì)胞收縮舒張生物學(xué)效應(yīng)的影響,以期為肌細(xì)胞相關(guān)疾病治療提供新思路。
[Abstract]:Myocyte specific microRNAs(muscle-specific microRNAs. MyomiRsis a kind of endogenous non-coding small molecule RNAs which is specifically expressed in muscle tissue. It is involved in a series of biological processes through the expression of genes related to negative regulation at post-transcriptional level. The occurrence and development of myocyte related diseases (such as chronic obstructive pneumonia, hypertrophic cardiomyopathy, etc.) may cause changes in the expression of myomiRs and its downstream target genes. This will further influence the development, prognosis and outcome of the disease. This article will review miR-1 miR-133 miR-206. The role of common myomiRs, such as miR-208 and miR-499, in the contractile and diastolic mechanisms of striated and non-striated muscles. Focus on the effects of myomiRs on the biological effects of myocyte contraction and relaxation in order to provide new ideas for the treatment of myocyte related diseases.
【作者單位】： 上海中醫(yī)藥大學(xué)上海市針灸經(jīng)絡(luò)研究所;
【基金】：國(guó)家自然科學(xué)基金(81473760,81574058) 上海市人才發(fā)展基金(201610) 上海市衛(wèi)生系統(tǒng)優(yōu)秀青年人才培養(yǎng)計(jì)劃(XYQ2013081) 上海市中醫(yī)藥事業(yè)發(fā)展三年行動(dòng)計(jì)劃重大研究項(xiàng)目(ZY3-CCCX-3-3005)~~
【分類(lèi)號(hào)】：R363
【正文快照】： *This work was supported by the National Natural Science Foundation of China(81473760,81574058),Shanghai TalentDevelopment Fund(201610),Training Plan for the Excellent Youth Scholars of Shanghai Health System(XYQ2013081)and theThree-year Action Plan for

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