本文關鍵詞：力學進展，由筆耕文化傳播整理發(fā)布。

圖書基本信息 出版時間：2011-5
出版社：高等教育出版社
作者：李少凡　等主編
頁數：284
書名：細胞力學進展 封面圖片 內容概要 《細胞力學進展》(英文版)從交叉學科的角度系統(tǒng)地介紹和總結了細胞力學和細胞物理研究領域的前沿課題和最新進展。其顯著的特點是用分子力學和復雜連續(xù)介質力學的方法研究和計算細胞的演變和分化；將定量的數學力學分析方法與實驗手段相結合來探討細胞的生物物理特性。
《細胞力學進展》(英文版)適合作為從事分子生物學、生物工程和力學、軟物質力學和物理、計算力學，，以及生物化學和醫(yī)學的科研人員和研究生的參考書。
《細胞力學進展》(英文版)的主編是美國加州大學伯克利分校的李少凡教授和南非科學院院士、開普半島科技大學的孫博華教授。 書籍目錄 Chapter 1 Modeling and Simulations of the Dynamics of Growing Cell
Clusters
1.1 Introduction
1.2 Single cell geometry and kinematics
1.2.1 The continuum model
1.2.2 The numerical model for the cell geometry
1.3 Single cell equilibrium and material model
1.3.1 Cell equilibrium
1.3.2 The material model
1.3.3 Determination of material constants
1.4 Modeling cell interactions
1.4.1 Cell-to-cell contact
1.4.2 Cell-to-cell adhesion
1.4.3 Cell-to-cell interaction test
1.5 Modeling the cell life cycle
1.6 Details of the numerical implementation
1.6.1 The finite element model
1.6.2 Contact/adhesion interface detection
1.6.3 Time integration
1.6.4 Parallelization
1.7 Numerical results
1.8 Summary and conclusions
References
Chapter 2 Multiscale Biomechanical Modeling of Stem
Cell-Extracellular Matrix Interactions
2.1 Introduction
2.2 Cell and ECM modeling
2.2.1 Basic hypothesis and assumptions
2.2.2 Hyperelastic model
2.2.3 Liquid crystal model
2.3 Contact and adhesion models for cell-substrate
interactions
2.3.1 The adhesive body force with continuum mechanics contact
2.3.2 The cohesive contact model
2.4 Meshfree Galerkin formulation and the computational
algorithm
2.5 Numerical simulations
2.5.1 Validation of the material rhodels
2.5.2 Cell response in four different stiffness substrates
2.5.3 Cell response to a stiffness-varying substrate
2.5.4 Comparison of two different contact algorithms
2.5.5 Three-dimensional simulation of cell spreading
2.6 Discussion and conclusions
References
Chapter 3 Modeling of Proteins and Their Interactions with Solvent
3.1 Introduction
3.2 Classical molecular dynamics
3.2.1 Coarse-grained model
3.2.2 High performance computing
3.3 Principal component analysis
3.3.1 Three oscillators system analysis with PCA
3.3.2 Quasi-harmonic analysis
3.3.3 Equilibrium conformational analysis
3.4 Methods and procedures
3.4.1 Framework
3.4.2 Overlap coefficients
3.4.3 Correlation analysis
3.4.4 PCA with MD simulation
3.4.5 Kabsch algorithm
3.4.6 Positional correlation matrix
3.4.7 Cluster analysis
3.5 MD simulation with T4 lysozyme
3.5.1 Equilibration measures
3.5.2 Fluctuation analysis
3.5.3 Mode selection and evaluation
3.5.4 Eigenvalue analysis
3.5.5 Overlap evaluation
3.5.6 Identification of slow conformational flexibility
3.5.7 Correlation analysis of T4 lysozyme
3.6 Hemoglobin and sickle cell anemia
3.6.1 Molecular dynamic simulation with NAMD
3.6.2 Conformational change analysis
3.6.3 PCA analysis
3.6.4 Correlation analysis with HbS interaction
3.7 Conclusion
References
Chapter 4 Structural， Mechanical and Functional Properties of
Intermediate Filaments from the Atomistic to the Cellular Scales
4.1 Introduction
4.1.1 Hierarchical structure of vimentin intermediate
filaments
4.1.2 The structural and physiological character of keratin
4.2 Connecting filaments to cells level function and pathology
4.2.1 Bending and stretching properties of IFs in cells
4.2.2 IFs responding differently to tensile and shear stresses
4.2.3 Mechanotransduction through the intermediate filament
network
4.3 Experimental mechanics
4.3.1 Single filament mechanics
4.3.2 Rheology of IF networks in vitro
4.3.3 IF networks rheology in cells
4.4 Case studies
4.4.1 Single vimentin filament mechanics
4.4.2 Network mechanics
4.4.3 The mechanical role of intermediate filament in cellular
system
4.5 Conclusion
References
Chapter 5 Cytoskeletal Mechanics and Rheology
5.1 Introduction
5.2 Modelling semiflexible filament dynamics
5.3 Experimental measurements
5.3.1 Glass microneedles
5.3.2 Cell poking
5.3.3 Atomic force microscopy
5.3.4 Micropipette aspiration
5.3.5 Microplates
5.3.6 Parallel-plate flow chambers
5.3.7 Optical tweezers
5.3.8 Magnetic traps
5.4 Computational models
5.5 Conclusion
References
Chapter 6 On the Application of Multiphasic Theories to the
Problem of Cell-substrate Mechanical Interactions
6.1 Introduction
6.2 The physics of contractile fibroblasts and their
interactions with an elastic substrate
6.2.1 Cell spreading, contractility and substrate elasticity
6.2.2 Molecular mechanisms of cell contractility
6.3 Multiphasic mixture theory and cell contractility
6.3.1 The cytoplasm as a quadriphasic medium
6.3.2 Mass transport and mass exchange within the cell
6.3.3 Contractility and force balance
6.3.4 Model's prediction for simple cases
6.4 Interaction between contractile cells and compliant
substrates
6.4.1 Two-dimensional plane stress formulation
6.4.2 Numerical strategy: XFEM-level methods
6.4.3 Analysis of mechanical interactions between a
contractile cell and an elastic substrate
6.5 Summary and conclusion
6.5.1 Summary
6.5.2 Limitations of the multiphasic approach
6.5.3 Concluding remark
References
Chapter 7 Effect of Substrate Rigidity on the Growth of Nascent
Adhesion Sites
7.1 Introduction
7.2 Model
7.3 Results and Discussion
7.4 Conclusion
References
Chapter 8 Opto-Hydrodynamic Trapping for Multiaxial Single-Cell
Biomechanics
8.1 Introduction
8.2 Optical-hydrodynamic trapping.
8.2.1 Optical physics and microfluidics
8.2.2 Theoretical stress analysis
8.2.3 Experimental and computational flow validation
8.2.4 Applied stresses and strain response
8.2.5 Multiaxial single-cell biomechanics
8.3 Discussion
References
Chapter 9 Application of Nonlocal Shell Models to Microtubule
Buckling in Living Cells
9.1 Introduction
9.2 Nonlocal shell theories
9.2.1 Constitutive relations
9.2.2 Shear deformable shell model
9.2.3 Thin shell model
9.3 Bending buckling analysis
9.4 Numerical results and discussion
9.5 Conclusions
Appendix A
Appendix B
Appendix C
Appendix D
References 章節(jié)摘錄 版權頁：插圖：In
this
method.the
fluid
flow
through
a
chamber
8urface
coated
with
a
cellmonolayer
iS
used
to
study
response
of
cells
to
fluid
flow；a
cellular
probe
iSused
to
measure
this
response.Several
cell
types
such
as
vascular
endothe-lial
cells
and
osteocytes
are
physiologically
exposed
to
fluid
flow
and
shearstress.Cells
sense
these
external
forces
and
react
accordingly；this
process
iscrucial
for
many
regulatory
processes.For
example，endothelial
surface
layerhas
multifaceted
physiological
functions
and
behaves
as
a
transport
barrier，as
a
porous
hydrodynamic
interface
in
the
motion
of
red
and
white
cells
inmicrovessels，and
as
a
mechanotransducer
of
fluid
shearing
stresses
to
theactin
cortical
cytoskeleton
of
the
endothelial
cell.Endothelial
cells
adoptan
elongated
shape
in
the
flow
direction
if
they
are
subjected
to
a
shear
flow.A
similar
situation
exists
for
osteocytes
in
bone
where
mechanosensing
con-trols
bone
repair
and
adaptive
restructuring
processes.It
iS
believed
thatstrain.derived
flow
of
interstitial
fluid
through
lacuno-canalicular
porositymechanically
activates
the
osteocytes.There
are
three
candidates
stimulat-ing
cells：wall
shear
stress.streaming
potentials.and
chemotransport.Controlling
the
wall
shear
stress
and
measuring
its
effect
on
fluid
transport.bone
cell
nitric
oxide，and
prostaglandin
production
can
be
used
to
study
thenature
of
the
flow-derived
cell
stimuli.Fluid
shear
stress
rate
iS
also
animportant
parameter
for
bone
cell
activation. 編輯推薦 《細胞力學進展(英文版)》是“十二五”國家重點圖書。 下載鏈接

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  本文關鍵詞：力學進展，由筆耕文化傳播整理發(fā)布。