【摘要】：目的:探討烏魯木齊部分地區(qū)碘營養(yǎng)狀態(tài)與甲狀腺癌的關系。方法:選取2014年3月-2014年12月在新疆醫(yī)科大學第一附屬醫(yī)院血管甲狀腺外科行手術治療并經(jīng)病理證實的甲狀腺良性結(jié)節(jié)患者158例為甲狀腺良性結(jié)節(jié)組、甲狀腺癌患者156例為甲狀腺癌組,及同期在新疆醫(yī)科大學第二附屬醫(yī)院體檢中心行甲狀腺超聲提示甲狀腺形態(tài)正常者301例為甲狀腺形態(tài)正常組。記錄三組一般資料、尿碘及血清甲狀腺功能、甲狀腺自身抗體表達水平,并進行比較分析。甲狀腺癌危險因素分析采用多因素Logistic回歸分析。結(jié)果:三組性別、年齡間差異有統(tǒng)計學意義(P0.05);而民族間差異無統(tǒng)計學意義(P0.05)。三組血清總?cè)饧紫僭彼?TT _3)、總甲狀腺素(TT4)、促甲狀腺激素(TSH)、甲狀腺球蛋白抗體(TgAb)、甲狀腺過氧化物酶抗體(TPOAb)水平間差異均有統(tǒng)計學意義(P0.05)。615例受試者尿碘中位數(shù)為[261.50(221.50)]μg/L,其中甲狀腺形態(tài)正常組為[257.60(169.35)]μg/L,甲狀腺良性結(jié)節(jié)組為[261.05(263.42)]μg/L,甲狀腺癌組為[297.90(374.40)]μg/L,三組間差異有統(tǒng)計學意義(P0.05);其中甲狀腺癌組與甲狀腺良性結(jié)節(jié)組、甲狀腺形態(tài)正常組比較,甲狀腺良性結(jié)節(jié)組與甲狀腺形態(tài)正常組比較,差異均有統(tǒng)計學意義(P0.05)。多因素Logistic回歸分析結(jié)果顯示,碘過量、女性、血清TgAb異常是甲狀腺癌的危險因素(P0.05)。結(jié)論:烏魯木齊地區(qū)人群碘缺乏狀態(tài)已糾正,并處于超適宜量水平,碘過量、女性、血清TgAb異常是甲狀腺癌的危險因素,建議該地區(qū)人群飲食上控制含碘食物及碘鹽的攝入。
[Abstract]:Objective: to investigate the relationship between iodine nutritional status and thyroid carcinoma in Urumqi. Methods: from March 2014 to December 2014, 158 patients with benign thyroid nodule were selected as thyroid benign nodule group, who were treated surgically and pathologically in the first affiliated Hospital of Xinjiang Medical University. 156 patients with thyroid cancer were diagnosed as thyroid carcinoma, and 301 patients with normal thyroid morphology were examined by thyroid ultrasound in the physical examination center of the second affiliated Hospital of Xinjiang Medical University. The general data of the three groups, urine iodine, serum thyroid function and thyroid autoantibody expression were recorded and compared. Multivariate Logistic regression analysis was used to analyze the risk factors of thyroid cancer. Results: there were significant differences in sex and age among the three groups (P0.05), but there was no significant difference among ethnic groups (P0.05). The levels of serum total triiodothyronine (TT _ 3), total thyroxine (TT4), thyroid stimulating hormone (TSH),) thyroglobulin antibody (TgAb),) thyroid peroxidase antibody (TPOAb) were significantly different among the three groups (P0.05). [261.50 (221.50)] 渭 g / L, including [257.60 (169.35) 渭 g / L, [261.05 (263.42) 渭 g / L, [297.90 (374.40)] 渭 g / L, in thyroid benign nodule group and thyroid carcinoma group, respectively (P0.05). The comparison of normal thyroid morphology group, thyroid benign nodule group and thyroid shape normal group, the difference was statistically significant (P0.05). Multivariate Logistic regression analysis showed that iodine overdose, female and serum TgAb abnormality were risk factors of thyroid carcinoma (P0.05). Conclusion: iodine deficiency status has been corrected in Urumqi area, and it is at the level of overdose. Iodine excess, female and serum TgAb abnormality are the risk factors of thyroid cancer. It is suggested that the intake of iodized food and iodized salt should be controlled in the diet of the population in Urumqi.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R736.1

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