本文關(guān)鍵詞： 高血壓 維生素D 超氧化物歧化酶 丙二醛 氧化應(yīng)激　出處：《山東醫(yī)藥》2016年31期 　論文類型：期刊論文

【摘要】：目的觀察維生素D不足或缺乏的高血壓患者血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量變化,并探討其意義。方法將已檢測維生素D的人群作為研究對(duì)象,其中高血壓患者58例納入高血壓組,血壓正常者71例納入對(duì)照組。高血壓組中,維生素D不足31例、維生素D缺乏27例;對(duì)照組中,維生素D不足30例、維生素D缺乏41例。采用羥胺測定法檢測血清SOD,采用硫代巴比妥酸測定法檢測血清MDA。結(jié)果高血壓組血清SOD活性降低,MDA含量升高,與對(duì)照組相比,P均0.05。高血壓組中,維生素D缺乏者血清SOD活性降低,MDA含量升高,與對(duì)照組相比,P均0.05;維生素D不足者M(jìn)DA含量升高,與對(duì)照組相比,P0.05。高血壓組中,維生素D缺乏者血清SOD活性降低,MDA含量升高,與維生素D不足者相比,P均0.05。對(duì)照組中,維生素D缺乏者血清MDA含量升高,與維生素D不足者相比,P均0.05。結(jié)論維生素D不足或缺乏的高血壓患者血清SOD活性降低,MDA含量升高,且在維生素D缺乏者變化更為明顯;維生素D缺乏可導(dǎo)致高血壓患者氧化應(yīng)激水平升高,并與高血壓的發(fā)病有關(guān)。
[Abstract]:Objective to observe the changes of serum superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in hypertensive patients with deficiency or deficiency of vitamin D. Among them, 58 patients with hypertension were included in the hypertension group and 71 patients with normal blood pressure were included in the control group. In the hypertension group, there were 31 cases of vitamin D deficiency, 27 cases of vitamin D deficiency, and 30 cases of vitamin D deficiency in the control group. Vitamin D deficiency was detected in 41 cases by hydroxylamine assay and by thiobarbituric acid method. Results Serum SOD activity in hypertension group was significantly lower than that in control group (P < 0.05). Compared with the control group, the serum SOD activity of the vitamin D deficient patients increased significantly, while that of the vitamin D deficiency group increased, and that of the vitamin D deficiency group increased. In the hypertension group, the serum SOD activity decreased in the vitamin D deficiency group, and increased in the vitamin D deficiency group compared with the control group, and the serum SOD activity in the vitamin D deficiency group was significantly lower than that in the control group. In the control group, the serum MDA content in the vitamin D deficient group was higher than that in the vitamin D deficiency group, and that in the vitamin D deficiency group was 0.05. Conclusion the serum SOD activity decreased in the hypertension patients with vitamin D deficiency or deficiency. Vitamin D deficiency can lead to the increase of oxidative stress in patients with hypertension, which is related to the pathogenesis of hypertension.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81070210)
【分類號(hào)】：R544.1

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