發(fā)布時間：2018-02-08 11:47

  本文關(guān)鍵詞： 中國 精神分裂癥 服藥依從性 危險因素 Meta分析　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:評價中國精神分裂癥患者服藥依從性影響因素,為臨床提高患者服藥依從性提供支持和指導(dǎo)意見。方法:從中英文數(shù)據(jù)庫中檢索有關(guān)中國精神分裂癥患者服藥依從性影響因素的文獻進行分析。通過英文檢索詞 "Schizophrenia*","Schizophrenic Disorder*","MedicationAdherence","Medication Persistence","Medication Compliance","Risk Factor*","Population*at Risk","China","Mainland China","Hong kong","Macao","Taiwan"和中文檢索詞"精神分裂癥"、"精神分裂性障礙""藥物治療依從性"、"服藥依從性""危險因素"、"影響因素"對萬方數(shù)據(jù)庫、中國知網(wǎng)(CNKI)、中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫(CBM)、Pubmed、Web of Science、Cochrane 和 Scopus 這 7 個國內(nèi)外數(shù)據(jù)庫進行文獻檢索。同時,對新期刊以及新文獻進行手工檢索。經(jīng)質(zhì)量評估后,收集數(shù)據(jù)。兩名研究人員分別獨立進行,不一致的信息由第三位研究人員再次核對。采用Review manger 5.3軟件對服藥依從性的影響因素進行合并分析。采用優(yōu)勢比(odds ratio,OR)和標準化均數(shù)差值(standardized mean difference,SMD)對分類指標和連續(xù)性指標分別衡量。并且,對異質(zhì)性≥50%的因素采用合并值敏感性分析法,發(fā)表偏倚采用漏斗圖進行檢驗。結(jié)果:本研究最終納入9篇文獻,合計分析了 12個指標,包括:患者年齡(歲)、性別、婚姻狀況、病程(年)、社會支持、藥物副作用、受教育程度(≥9年)、工作情況、支付能力、服用的藥物種數(shù)、醫(yī)患關(guān)系以及患者的自知力。本研究顯示4個因素與服藥依從性關(guān)聯(lián)有統(tǒng)計學(xué)意義,分別是社會支持:OR=3.19,95%CI:1.18～8.64,PQ0.00001,P=0.02;藥物副作用:OR=0.35,95%CI:0.18～0.68,PQ=0.0001,P P=0.002;支付能力:OR=1.92,95%CI:1.09～3.40,PQ=0.0006,P=0.02;患者自知力:OR=5.51,95%CI:1.42～21.42,PQ=0.05,P=0.01。結(jié)論:中國精神分裂癥患者服藥依從性的主要影響因素為:社會支持、藥物副作用、支付能力及患者自知力。
[Abstract]:Objective: to evaluate the influencing factors of drug compliance in Chinese schizophrenic patients. To provide support and guidance for clinical improvement of patients' compliance with medication. Methods: to search the literature on the influencing factors of Chinese schizophrenic patients' compliance with medication from the database of Chinese and English. "Schizophrenia *", "Schizophrenic Disorder *", "MedicationAdherence", "Medication Persistence", "Medication Compliance", "Risk Factor*", "Population*at Risk", "China", "Mainland China", "Hong kong", "Macao", "Taiwan" and the Chinese key words "schizophrenia", "schizophrenia", "Drug Compliance", "medication Compliance", "risk factors", "influencing factors" to Wanfang Database, CNKI, China Biomedical Literature Database (CBM), Pubmedan Web of Science Cochrane and Scopus, seven domestic and foreign databases, are searched for literature. At the same time, new journals and new documents are searched manually. After quality evaluation, Collecting data. The two researchers did it independently. Inconsistent information was rechecked by a third researcher. The factors affecting drug compliance were analyzed using Review manger 5.3 software. Odds odds ratios and standardized mean differences were used to evaluate the classification and continuous use of SMDs. Sex indicators measure... And, The factors of heterogeneity 鈮，

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