【摘要】：目的了解天津市紅橋醫(yī)院臨床分離鮑曼不動桿菌的分布特征與耐藥性,為合理使用抗菌藥物提供依據(jù)。方法回顧性分析2010年1月-2015年12月臨床分離鮑曼不動桿菌的標本分布與藥敏試驗結(jié)果。結(jié)果共收集鮑曼不動桿菌783株,主要來自痰標本,占81.0%,其次是咽拭子,占10.2%;科室分布以呼吸內(nèi)科和重癥監(jiān)護病房為主,分別占41.6%、23.4%。該菌對頭孢哌酮/舒巴坦和米諾環(huán)素的耐藥率最低,分別為2.55%、4.34%;耐藥率最高的抗菌藥物為氨曲南和甲氧芐啶/磺胺甲VA唑,分別為62.71%、35.89%;對其他β-內(nèi)酰胺類、頭孢菌素類、氨基糖苷類、喹諾酮類等抗菌藥物的耐藥率保持在20.0%~35.0%之間;除對頭孢哌酮/舒巴坦、米諾環(huán)素、美羅培南連續(xù)6年間耐藥率變化無明顯差異(P0.05),其他15種抗生素6年間的耐藥率變化均差異明顯(P0.05)。臨床分離鮑曼不動桿菌對美羅培南和亞胺培南耐藥率分別由2010年的5.58%和5.58%上升到2015年的10.42%和14.58%。連續(xù)6年多重耐藥鮑曼不動桿菌總檢出率為15.5%,各年度間檢出率差異無統(tǒng)計學意義(P0.05)。結(jié)論該院臨床治療鮑曼不動桿菌引起感染的經(jīng)驗性用藥,可選擇氨基糖苷類、喹諾酮類、頭孢菌素類等藥物,盡量在藥敏試驗結(jié)果指導下合理選用抗菌藥物。
[Abstract]:Objective to investigate the distribution and drug resistance of Acinetobacter baumannii isolated in Hongqiao Hospital of Tianjin. Methods the distribution and drug sensitivity of Acinetobacter baumannii isolated from January 2010 to December 2015 were analyzed retrospectively. Results A total of 783 strains of Acinetobacter baumannii were collected, mainly from sputum, accounting for 81.0, followed by swabs of pharynx, accounting for 10.2. The resistance rates of cefoperazone / sulbactam and minocycline were the lowest, 2.55 and 4.34, respectively. The highest resistance rates were amtreonam and trimethoprim / sulfamethoxazole (62.71and 35.89cm, respectively; for other 尾 -lactams, cephalosporins, cephalosporins). The resistance rate of aminoglycosides, quinolones and other antimicrobial agents remained between 20.0% and 35.0%, except for cefoperazone / sulbactam, minocycline, minocycline, There was no significant difference in drug resistance rate of meropenem for 6 consecutive years (P0.05), but there was significant difference in resistance rate of other 15 antibiotics in 6 years (P0.05). The resistance rates of Acinetobacter baumannii to meropenem and imipenem increased from 5.58% and 5.58% in 2010 to 10.42% and 14.58% in 2015, respectively. The total detection rate of Acinetobacter baumannii for 6 consecutive years was 15.5. there was no significant difference in detection rate between different years (P0.05). Conclusion in clinical treatment of Acinetobacter baumannii infection, aminoglycosides, quinolones, cephalosporins and other drugs can be selected.
【作者單位】： 天津醫(yī)科大學研究生院;天津市紅橋醫(yī)院;天津醫(yī)科大學總醫(yī)院;
【分類號】：R446.5

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本文編號：2238429