承德市體檢人群甲狀腺結(jié)節(jié)患病情況及危險(xiǎn)因素研究
發(fā)布時(shí)間：2018-09-07 21:07
【摘要】：目的:通過(guò)對(duì)承德市體檢人群甲狀腺結(jié)節(jié)患病情況的橫斷面研究,了解承德市體檢人群甲狀腺結(jié)節(jié)患病率情況;在此基礎(chǔ)上自行編制具有承德特色的甲狀腺結(jié)節(jié)相關(guān)因素調(diào)查問(wèn)卷,用于體檢人群甲狀腺結(jié)節(jié)患病危險(xiǎn)因素的病例對(duì)照研究,了解其患甲狀腺結(jié)節(jié)的危險(xiǎn)因素,為制定承德市甲狀腺結(jié)節(jié)防治措施、臨床醫(yī)護(hù)人員進(jìn)行健康宣教提供理論指導(dǎo)和科學(xué)依據(jù)。方法:本課題采用以體檢人群為基礎(chǔ)的橫斷面調(diào)查及病例對(duì)照研究方法,收集2015年1月~2016年1月在承德市某三甲醫(yī)院健康體檢中心查體的18~90歲體檢者的血液生化檢查、B型超聲檢查、體格檢查及身體測(cè)量等檢測(cè)項(xiàng)目的結(jié)果,描述性分析承德市體檢人群中甲狀腺結(jié)節(jié)患病率及其它疾病的檢出情況;同時(shí)在體檢人群中選取符合診斷標(biāo)準(zhǔn)的200例新發(fā)甲狀腺結(jié)節(jié)陽(yáng)性者作為病例組,按照同期、年齡(±3歲)選取無(wú)甲狀腺結(jié)節(jié)的200例體檢者作為對(duì)照組,應(yīng)用自編的《甲狀腺結(jié)節(jié)相關(guān)因素調(diào)查問(wèn)卷》對(duì)兩組人群生活飲食、社會(huì)心理及疾病家族史等影響因素進(jìn)行問(wèn)卷調(diào)查,數(shù)據(jù)整理后,進(jìn)行單因素及多因素非條件logistic回歸分析,進(jìn)一步探討承德市體檢人群甲狀腺結(jié)節(jié)患病的相關(guān)危險(xiǎn)因素。結(jié)果:1承德市體檢人群甲狀腺結(jié)節(jié)橫斷面研究結(jié)果:6000例健康體檢居民中,有效的統(tǒng)計(jì)數(shù)據(jù)資料為5462例(男性3218例、女性2244例)。甲狀腺結(jié)節(jié)總患病率為40.72%,其中女性人群甲狀腺結(jié)節(jié)患病率為42.47%,男性人群甲狀腺結(jié)節(jié)患病率為39.53%,女性甲狀腺結(jié)節(jié)患病率高于男性,差異有統(tǒng)計(jì)學(xué)意義(χ2=4.64,P=0.031)。甲狀腺結(jié)節(jié)患病率與年齡的增長(zhǎng)成正相關(guān)趨勢(shì),60歲年齡段人群結(jié)節(jié)患病率最高,達(dá)到64.19%。多因素分析發(fā)現(xiàn)年齡(OR=1.032,P=0.000)、體重指數(shù)(OR=1.021,P=0.042)、空腹血糖(OR=2.101,P=0.037)是體檢人群中甲狀腺結(jié)節(jié)患病率較高的獨(dú)立影響因素。2承德市體檢人群甲狀腺結(jié)節(jié)危險(xiǎn)因素病例對(duì)照研究結(jié)果:經(jīng)單因素及多因素非條件Logistic回歸分析后,甲狀腺疾病家族史(OR=5.17,P=0.010)、長(zhǎng)期熬夜(OR=4.87,P=0.010)、經(jīng)常生氣(OR=3.32,P=0.000)及食用碘鹽(OR=3.13,P=0.000)可能為體檢人群患甲狀腺結(jié)節(jié)的危險(xiǎn)因素;家庭生活關(guān)系和諧(OR=-1.07,P=0.000)、積極的自我看法(OR=-0.44,P=0.016)可能為體檢人群患甲狀腺結(jié)節(jié)的保護(hù)因素。結(jié)論:1承德市體檢人群甲狀腺結(jié)節(jié)總患病率為40.72%。其中,女性甲狀腺結(jié)節(jié)患病率氋于男性,且患病率隨年齡增長(zhǎng)而逐漸升高,60歲年齡段人群結(jié)節(jié)患病率高達(dá)64.19%,提示:應(yīng)對(duì)我市居民甲狀腺結(jié)節(jié)的流行現(xiàn)況引起更多關(guān)注。2甲狀腺結(jié)節(jié)受多種影響因素的綜合作用,建議居民及高危人群應(yīng)該從膳食、生活方式、改善社會(huì)心理環(huán)境等多方面采取預(yù)防控制措施,對(duì)年齡60歲及有甲狀腺疾病家族史的高危人群,應(yīng)重點(diǎn)進(jìn)行監(jiān)測(cè),以期預(yù)防疾病的發(fā)生。
[Abstract]:Objective: to investigate the prevalence rate of thyroid nodules in healthy people in Chengde city by cross-sectional study. On the basis of this, the questionnaire of thyroid nodule related factors with Chengde characteristic was compiled, which was used in the case-control study of thyroid nodule risk factors in physical examination population to find out the risk factors of thyroid nodule. In order to make the prevention and cure measures of thyroid nodule in Chengde City, and provide the theory guidance and scientific basis for the health education of the clinical medical staff. Methods: a cross-sectional investigation and a case-control study based on physical examination were used in this study. From January 2015 to January 2016, the results of the blood biochemical examination, physical examination and physical measurement of 180-year-old people who were examined in the health examination center of a third Class A Hospital in Chengde City were collected, such as B-mode ultrasound examination, physical examination and physical measurement, etc. The prevalence of thyroid nodules and the detection of other diseases were analyzed in Chengde City, and 200 newly diagnosed thyroid nodule positive patients were selected as the case group according to the same period. The age (鹵3 years) of 200 healthy persons without thyroid nodule were selected as control group. The self-designed questionnaire of thyroid nodule related factors was used to investigate the influencing factors such as diet, social psychology and family history of disease in the two groups. Univariate and multivariate non-conditional logistic regression analysis was carried out to further explore the risk factors of thyroid nodule in healthy population in Chengde city. Results the results of the cross-sectional study of thyroid nodules in the population in Chengde City showed that the effective statistical data were 5462 cases (3218 males and 2244 females) out of 6 000 healthy residents. The total prevalence rate of thyroid nodules was 40.72%. The prevalence rate of thyroid nodules was 42.47 in female population and 39.53 in male population. The prevalence rate of thyroid nodule in female was higher than that in male (蠂 ~ 2 = 4.64) (蠂 ~ 2 = 4.64). The incidence of thyroid nodule was positively correlated with the increase of age. The prevalence rate of thyroid nodule was the highest in the age group of 60 years old, reaching 64.19%. Multivariate analysis found that age (OR=1.032,P=0.000), body mass index (OR=1.021,P=0.042) and fasting blood glucose (OR=2.101,P=0.037) were independent factors influencing the prevalence of thyroid nodules. After univariate and multivariate unconditioned Logistic regression analysis, Family history of thyroid disease (OR=5.17,P=0.010), long stay up (OR=4.87,P=0.010), frequent anger (OR=3.32,P=0.000) and iodized salt (OR=3.13,P=0.000) may be the risk factors of thyroid nodule in healthy people. Harmonious family life (OR=-1.07,P=0.000) and positive self-perception (OR=-0.44,P=0.016) may be the protective factors for thyroid nodules. Conclusion the total prevalence rate of thyroid nodules in the population in Chengde City is 40.72. Among them, the prevalence of thyroid nodules in females was higher than that in males. The prevalence rate of thyroid nodules increased gradually with the increase of age, and the prevalence rate of thyroid nodules was 64.19, which suggested that more attention should be paid to the prevalence of thyroid nodules in the residents of our city. It is suggested that the residents and high risk groups should take preventive and control measures from the aspects of diet, lifestyle, and improvement of social and psychological environment, and should focus on monitoring the high risk population aged 60 years and having a family history of thyroid diseases. In order to prevent the occurrence of disease.
【學(xué)位授予單位】：承德醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R473.5
本文編號(hào)：2229420
[Abstract]:Objective: to investigate the prevalence rate of thyroid nodules in healthy people in Chengde city by cross-sectional study. On the basis of this, the questionnaire of thyroid nodule related factors with Chengde characteristic was compiled, which was used in the case-control study of thyroid nodule risk factors in physical examination population to find out the risk factors of thyroid nodule. In order to make the prevention and cure measures of thyroid nodule in Chengde City, and provide the theory guidance and scientific basis for the health education of the clinical medical staff. Methods: a cross-sectional investigation and a case-control study based on physical examination were used in this study. From January 2015 to January 2016, the results of the blood biochemical examination, physical examination and physical measurement of 180-year-old people who were examined in the health examination center of a third Class A Hospital in Chengde City were collected, such as B-mode ultrasound examination, physical examination and physical measurement, etc. The prevalence of thyroid nodules and the detection of other diseases were analyzed in Chengde City, and 200 newly diagnosed thyroid nodule positive patients were selected as the case group according to the same period. The age (鹵3 years) of 200 healthy persons without thyroid nodule were selected as control group. The self-designed questionnaire of thyroid nodule related factors was used to investigate the influencing factors such as diet, social psychology and family history of disease in the two groups. Univariate and multivariate non-conditional logistic regression analysis was carried out to further explore the risk factors of thyroid nodule in healthy population in Chengde city. Results the results of the cross-sectional study of thyroid nodules in the population in Chengde City showed that the effective statistical data were 5462 cases (3218 males and 2244 females) out of 6 000 healthy residents. The total prevalence rate of thyroid nodules was 40.72%. The prevalence rate of thyroid nodules was 42.47 in female population and 39.53 in male population. The prevalence rate of thyroid nodule in female was higher than that in male (蠂 ~ 2 = 4.64) (蠂 ~ 2 = 4.64). The incidence of thyroid nodule was positively correlated with the increase of age. The prevalence rate of thyroid nodule was the highest in the age group of 60 years old, reaching 64.19%. Multivariate analysis found that age (OR=1.032,P=0.000), body mass index (OR=1.021,P=0.042) and fasting blood glucose (OR=2.101,P=0.037) were independent factors influencing the prevalence of thyroid nodules. After univariate and multivariate unconditioned Logistic regression analysis, Family history of thyroid disease (OR=5.17,P=0.010), long stay up (OR=4.87,P=0.010), frequent anger (OR=3.32,P=0.000) and iodized salt (OR=3.13,P=0.000) may be the risk factors of thyroid nodule in healthy people. Harmonious family life (OR=-1.07,P=0.000) and positive self-perception (OR=-0.44,P=0.016) may be the protective factors for thyroid nodules. Conclusion the total prevalence rate of thyroid nodules in the population in Chengde City is 40.72. Among them, the prevalence of thyroid nodules in females was higher than that in males. The prevalence rate of thyroid nodules increased gradually with the increase of age, and the prevalence rate of thyroid nodules was 64.19, which suggested that more attention should be paid to the prevalence of thyroid nodules in the residents of our city. It is suggested that the residents and high risk groups should take preventive and control measures from the aspects of diet, lifestyle, and improvement of social and psychological environment, and should focus on monitoring the high risk population aged 60 years and having a family history of thyroid diseases. In order to prevent the occurrence of disease.
【學(xué)位授予單位】：承德醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R473.5
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