發(fā)布時間：2018-05-02 01:54

  本文選題：手足口病 + 柯薩奇病毒　； 參考：《中華醫(yī)院感染學雜志》2017年19期

【摘要】：目的分析本地區(qū)兒童手足口病的病原學特征,為臨床診治和防控提供依據。方法隨機抽取2015年1月-2016年12月臨床診斷手足口病患兒316例,采集鼻咽拭子樣本應用實時熒光定量RT-PCR方法檢測腸道病毒通用型、柯薩奇病毒A組16型(Cox A16)和腸道病毒71型(EV71)。結果 316例鼻咽拭子樣本中共檢出腸道病毒164例占51.90%,Cox A16 38例占12.03%,EV71 47例占14.87%,其他腸道病毒79例占25.00%,各型檢出率總體差異有統(tǒng)計學意義(P0.05);2015-2016年腸道病毒、Cox A16、EV71和其他腸道病毒檢出率分別為47.12%、3.14%、22.51%、21.47%和59.20%、25.60%、3.20%、30.40%,除其他腸道病毒各型在年度間檢出率差異均有統(tǒng)計學意義(P0.05);各型在性別間檢出率差異均無統(tǒng)計學意義;手口病主要集中在1、2和3歲組,共占70.25%,腸道病毒核酸陽性也集中在1、2、和3歲組。結論監(jiān)控傳染源,保護易感人群,選取合適標本類型和加強其他腸道病毒分型是手足口病的診治和防控重點工作。
[Abstract]:Objective to analyze the etiological characteristics of hand, foot and mouth disease (HFMD) in children in this area and to provide evidence for clinical diagnosis, treatment and prevention and control. Methods 316 cases of hand-foot-mouth disease were randomly selected from January 2015 to December 2016. Nasopharyngeal swabs were collected and detected by real-time fluorescence quantitative RT-PCR. Coxsackie virus A group 16 Cox A16) and enterovirus 71 EV71 were detected. Results 164 cases (51.90%) of Enterovirus were detected in 316 nasopharyngeal swabs samples, 164 cases (51.90%) were detected by Cox A16, 38 cases (12.03%) had EV71,47 cases (14.8775%), and 79 cases of other enterovirus viruses (25.00%). The overall detection rate of enterovirus was statistically significant (P 0.05) and Cox A16EV71 and other enteric tract viruses were detected in 2015-2016. The detectable rate of virus was 21.47% and 59.20%, respectively. There were significant differences in the detection rates of other enterovirus types among different types of enterovirus in different years (P 0.05%, P 0.05%, P 0.05%, P 0.05%, P 0.05%, P 0.05%, P 0.05%, respectively), and there was no significant difference between the two sexes in the detection rate of each type, among which there was no significant difference in the detection rate of other enterovirus types between the two sexes (P 0.05%). Hand-mouth disease was mainly concentrated in the group of 1 and 3 years old (70.25%), and the positive rate of enterovirus nucleic acid was also concentrated in the group of 1 2 years old and 3 years old group. Conclusion Surveillance of infection source, protection of susceptible population, selection of appropriate specimen types and strengthening of other enterovirus typing are the key tasks of diagnosis, treatment, prevention and control of hand, foot and mouth disease.
【作者單位】： 浙江省寧海縣第一醫(yī)院檢驗科;寧波市疾病預防控制中心;
【基金】：寧波市自然科學基金資助項目(2014A610288)
【分類號】：R440;R725.1

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