本文選題：胃　切入點：幽門螺旋桿菌　出處：《重慶郵電大學》2016年碩士論文

【摘要】：隨著生活節(jié)奏的加快,越來越多的人受消化道疾病的困擾。寄生于人體胃區(qū)的幽門螺旋桿菌是引起諸多消化道疾病的元兇,而目前主要采用藥物來治療菌該類疾病。但藥物殺菌根除率不高,且隨著抗菌藥物的濫用,細菌的耐藥性越來越強。藍光殺菌作為一種物理殺菌方法,具有高效、安全、細菌不會產生抗性等優(yōu)點。體外與臨床實驗研究表明,特定波長的藍光能夠有效殺死幽門螺桿菌,根除率高。目前,該技術只局限于在臨床實驗,且實驗設備存在體積大、有創(chuàng)等不足。本課題研究了一種針對胃區(qū)幽門螺旋桿菌的微型化殺菌技術,改變了光源進入人體胃區(qū)光療的方式,具有體積小、無創(chuàng)的特性。本文主要工作包括如下:1.討論了空腹期胃區(qū)光療模型并分析了胃運動對其影響,仿真了光療光源。通過對胃結構形態(tài)及運動模式分析,論證了空腹期胃腔在不同相運動模式下對光療模型的影響與光源設計。最后,對LED燈組光源進行了仿真。2.設計了基于LED的微型化藍光殺菌裝置。該微型化殺菌裝置主要由LED光療模塊、pH傳感、主控與無線通信模塊、電源管理模塊等構成。該裝置采用基于pH傳感的啟停光療方案,通過對裝置在消化道位置追蹤,實現(xiàn)工作狀態(tài)調控。3.通過實驗測量數(shù)據(jù),測試了pH傳感器的測量精度,并擬合了其測量曲線。同時測試其響應時間與啟停功能,結果顯示符合設計要求。針對測量干擾,提出基于集合經驗模態(tài)分解自動重構的抗干擾算法,以提高抗干擾能力與測量準確性。4.通過實驗測試,驗證了光療模塊在不同功率輸出模式下系統(tǒng)工作效率,測定輸出能量是否符合設計要求。同時,測試了各功能模塊的功耗,分析了功耗比的合理性。結果表明,各項參數(shù)符合本文設計要求。本課題研究的藍光殺菌技術,其主要目的是在空腹期對胃腔幽門螺旋桿菌進行殺滅,達到治愈疾病的效果,具有微型化、無創(chuàng)等優(yōu)點。對該技術進一步研究與完善,將極大提高藍光殺菌技術在臨床的應用價值。
[Abstract]:As the pace of life accelerates, more and more people suffer from digestive tract diseases. Helicobacter pylori, parasitic in the human stomach, is responsible for many digestive tract diseases. But the bactericidal eradication rate is not high, and with the abuse of antimicrobial agents, bacterial resistance is becoming stronger and stronger. As a physical sterilization method, blue ray sterilization has high efficiency and safety. Studies in vitro and in clinical trials show that specific wavelengths of blue light can effectively kill Helicobacter pylori and have a high eradication rate. At present, the technique is limited to clinical trials, and the experimental equipment has a large volume. In this paper, a miniaturized bactericidal technique for Helicobacter pylori in the gastric region was studied, which changed the way of light source entering the gastric area of the human body and had a small size. The main work of this paper is as follows: 1.Discusses the model of phototherapy of stomach area in fasting period, analyzes the influence of gastric movement on it, and simulates the light source of phototherapy. The effect of fasting gastric cavity on phototherapy model and the design of light source in different phase motion mode are demonstrated. Finally, The light source of LED lamp set is simulated. 2. The miniaturized blue light sterilizing device based on LED is designed. The miniaturized sterilizing device is mainly composed of pH sensing module of LED phototherapy module, main control module and wireless communication module. The device adopts the scheme of starting and stopping light therapy based on pH sensor, and realizes the working state control by tracking the position of the device in the digestive tract. The measuring accuracy of the pH sensor is tested through the experimental measurement data. At the same time, the response time and the function of starting and stopping are tested, and the results show that it meets the design requirements. An anti-jamming algorithm based on the set empirical mode decomposition automatic reconstruction is proposed for the measurement interference. In order to improve anti-interference ability and accuracy of measurement .4.Through experimental tests, the system efficiency of phototherapy module under different power output modes is verified, and the output energy is measured to meet the design requirements. At the same time, the power consumption of each functional module is tested. The rationality of power consumption ratio is analyzed. The results show that the parameters meet the requirements of the design of this paper. The main purpose of the blue ray sterilization technique is to kill Helicobacter pylori in the stomach cavity on an empty stomach, so as to cure the disease. It has the advantages of miniaturization, noninvasive and so on. Further research and improvement of this technology will greatly improve the application value of blue ray sterilization technology in clinic.
【學位授予單位】：重慶郵電大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R454

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