本文選題：高效液相色譜-質(zhì)譜聯(lián)用　切入點(diǎn)：生物化學(xué)　出處：《中國新藥雜志》2017年19期 　論文類型：期刊論文

【摘要】：近年來,高效液相色譜-質(zhì)譜聯(lián)用(HPLC-MS)技術(shù)在生物化學(xué)(蛋白質(zhì)、肽和核酸)、環(huán)境保護(hù)、醫(yī)藥研究等方面應(yīng)用廣泛。該技術(shù)不僅具有HPLC對(duì)復(fù)雜樣品的高分離效能、儀器自動(dòng)化等特點(diǎn),而且還具有MS的高專屬性、高靈敏度、高選擇性、分析速度快和強(qiáng)大結(jié)構(gòu)測(cè)定的優(yōu)勢(shì)。隨著現(xiàn)代化高新技術(shù)的發(fā)展,HPLC-MS憑借自身的技術(shù)優(yōu)勢(shì),必將在未來多個(gè)重要領(lǐng)域的檢測(cè)中發(fā)揮越來越重要的作用。脂肪酸(fatty acids,FA)是由碳、氫、氧3種元素組成的一類有機(jī)化合物,其在有充足氧供給的情況下,可氧化分解為CO_2和H_2O,釋放大量能量,為機(jī)體主要能量來源之一。本文綜述了HPLC-MS技術(shù)在檢測(cè)不同樣本中FA的應(yīng)用,對(duì)其存在的問題進(jìn)行討論,并對(duì)其在生物化學(xué)領(lǐng)域的應(yīng)用前景進(jìn)行展望。
[Abstract]:In recent years, high performance liquid chromatography-mass spectrometry (HPLC-MS) has been widely used in biochemistry (protein, peptide and nucleic acid), environmental protection, medical research, etc. With the development of modern high technology, HPLC-MS has its own advantages, such as high quality, high sensitivity, high selectivity, fast analysis and powerful structure measurement. Fatty acid fatty acids (fatty acids) are a class of organic compounds composed of carbon, hydrogen and oxygen, which can be supplied with sufficient oxygen. It can be decomposed into CO_2 and H _ 2O, releasing a large amount of energy, which is one of the main energy sources of the body. This paper reviews the application of HPLC-MS technology in the detection of FA in different samples, and discusses its existing problems. The prospect of its application in the field of biochemistry is prospected.
【作者單位】： 陜西中醫(yī)藥大學(xué)藥學(xué)院;第四軍醫(yī)大學(xué)西京醫(yī)院藥劑科;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81470174)
【分類號(hào)】：O657.63;R446.1

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