發(fā)布時間：2018-04-17 02:34

  本文選題：人工耳蝸 + 脈沖激光��； 參考：《清華大學學報(自然科學版)》2017年10期

【摘要】：近年來以脈沖激光誘發(fā)聽神經(jīng)響應的研究逐步深入,然而目前國內外對于光刺激聽神經(jīng)的機理研究尚未有定論。該文利用仿真軟件COMSOL Multiphysics研究了三維模型脈沖激光刺激耳蝸產(chǎn)生的光熱現(xiàn)象和光聲現(xiàn)象,同時結合活體豚鼠實驗結果分析了光刺激聽神經(jīng)的機理。結果顯示:仿真中光刺激聽神經(jīng)產(chǎn)生了溫升,也引發(fā)了光聲效應;活體動物實驗中光刺激在藥物急性致聾的豚鼠中誘發(fā)出復合聽神經(jīng)動作電位。結果分析表明:光刺激耳蝸產(chǎn)生的響應更可能是光聲效應和光熱效應共同作用的結果。
[Abstract]:In recent years, the response of auditory nerve induced by pulsed laser has been studied step by step. However, the mechanism of optical stimulation of auditory nerve has not been concluded at home and abroad.In this paper, the photothermal and photoacoustic phenomena produced by three-dimensional pulsed laser stimulation of cochlea were studied by COMSOL Multiphysics, and the mechanism of photostimulation of auditory nerve was analyzed in combination with the experimental results of guinea pigs in vivo.The results showed that photostimulation of auditory nerve produced temperature rise and photoacoustic effect, and in vivo animal experiment, photostimulation induced compound auditory nerve action potential in guinea pigs with acute deafness induced by drugs.The results showed that the response of the cochlea stimulated by light was more likely to be the result of the combination of photoacoustic effect and photothermal effect.
【作者單位】： 清華大學深圳研究生院生物醫(yī)學工程研究中心;清華大學生物醫(yī)學工程系;深圳信息職業(yè)技術學院電子與通信學院;
【基金】：國家自然科學基金資助項目(31271056,81401539)
【分類號】：R764;TP391.9

【相似文獻】

相關期刊論文 前2條

1 俞素勤,張晰,許迅;微脈沖激光技術在眼科的應用[J];中國實用眼科雜志;2004年07期

2 王光霽,Oleg Pomerantzeff;多次脈沖激光與連續(xù)激光在視網(wǎng)膜光凝作用中之比較[J];溫州醫(yī)學院學報;1989年04期

相關碩士學位論文 前1條

1 梁燕華;閾值下810nm微脈沖激光對糖尿病大鼠視網(wǎng)膜病變治療機制的研究[D];南方醫(yī)科大學;2016年

，

本文編號：1761705