中國高尿酸血癥患者HLA-B58:01基因的人群分布
發(fā)布時間：2018-11-14 17:18
【摘要】：目的全面了解中國大陸各地區(qū)HLA-B*58:01基因的陽性率和頻率,有效地指導高尿酸血癥患者臨床用藥及臨床基因篩查的必要性。方法對中華骨髓庫891 793例中國大陸人群行HLA高分辨分型,并按31個省市自治區(qū)分層,明確HLA-B*58:01基因陽性率和基因頻率。結(jié)果中國大陸人群HLA-B*58:01基因陽性率呈現(xiàn)南方人群中較其他地區(qū)高;按地區(qū)分類,華南地區(qū)的HLA-B*58:01基因陽性率最高,西南地區(qū)及北方地區(qū)陽性率較低;按省市自治區(qū)分類,陽性率較高的分別為福建(28.43%)、廣西(20.75%)、海南(20.20%)、廣東(19.66%)、浙江(18.38%),陽性率較低的為天津(3.52%)、內(nèi)蒙古(3.49%)、西藏(3.27%)、河北(3.11%)、山西(3.08%)。結(jié)論重視高尿酸血癥HLA-B*58:01基因陽性人群,尤其應對中國南方人群高尿酸血癥患者進行HLA-B*58:01基因篩查,以避免使用別嘌呤醇所致嚴重不良后果。
[Abstract]:Objective to understand the positive rate and frequency of HLA-B*58:01 gene in different regions of mainland China, and to effectively guide clinical drug use and gene screening in patients with hyperuricemia. Methods High-resolution HLA typing was performed in 891,793 Chinese mainland population. The positive rate and frequency of HLA-B*58:01 gene were determined according to 31 provinces and autonomous regions. Results the positive rate of HLA-B*58:01 gene in the population of mainland China was higher than that in other regions, and the positive rate of HLA-B*58:01 gene in South China was the highest, and the positive rate of HLA-B*58:01 gene was lower in the southwest and north of China. The positive rates were higher in Fujian (28.43%), Guangxi (20.75%), Hainan (20.20%), Guangdong (19.66%) and Zhejiang (18.38%), respectively. The positive rates were lower in Tianjin (3.52%), Inner Mongolia (3.49%), Tibet (3.27%), Hebei (3.11%) and Shanxi (3.08%). Conclusion attention should be paid to the HLA-B*58:01 gene positive population with hyperuricemia, especially the patients with hyperuricemia in southern China should be screened for HLA-B*58:01 gene, so as to avoid the serious adverse consequences caused by allopurinol.
【作者單位】： 南京醫(yī)科大學第一附屬醫(yī)院HLA與移植免疫實驗中心;北京市紅十字血液中心;中華骨髓庫質(zhì)量控制實驗室;重慶市血液中心;河北省血液中心;中國醫(yī)學科學院輸血研究所;遼寧省血液中心;山西省太原市紅十字中心血站;遼寧省大連市紅十字血液中心;中國造血干細胞捐獻者資料庫管理中心技術服務部;南京醫(yī)科大學第一附屬醫(yī)院內(nèi)分泌科;
【基金】：江蘇省衛(wèi)生和計劃生育委員會科技項目(Z201401)
【分類號】：R589.7
[Abstract]:Objective to understand the positive rate and frequency of HLA-B*58:01 gene in different regions of mainland China, and to effectively guide clinical drug use and gene screening in patients with hyperuricemia. Methods High-resolution HLA typing was performed in 891,793 Chinese mainland population. The positive rate and frequency of HLA-B*58:01 gene were determined according to 31 provinces and autonomous regions. Results the positive rate of HLA-B*58:01 gene in the population of mainland China was higher than that in other regions, and the positive rate of HLA-B*58:01 gene in South China was the highest, and the positive rate of HLA-B*58:01 gene was lower in the southwest and north of China. The positive rates were higher in Fujian (28.43%), Guangxi (20.75%), Hainan (20.20%), Guangdong (19.66%) and Zhejiang (18.38%), respectively. The positive rates were lower in Tianjin (3.52%), Inner Mongolia (3.49%), Tibet (3.27%), Hebei (3.11%) and Shanxi (3.08%). Conclusion attention should be paid to the HLA-B*58:01 gene positive population with hyperuricemia, especially the patients with hyperuricemia in southern China should be screened for HLA-B*58:01 gene, so as to avoid the serious adverse consequences caused by allopurinol.
【作者單位】： 南京醫(yī)科大學第一附屬醫(yī)院HLA與移植免疫實驗中心;北京市紅十字血液中心;中華骨髓庫質(zhì)量控制實驗室;重慶市血液中心;河北省血液中心;中國醫(yī)學科學院輸血研究所;遼寧省血液中心;山西省太原市紅十字中心血站;遼寧省大連市紅十字血液中心;中國造血干細胞捐獻者資料庫管理中心技術服務部;南京醫(yī)科大學第一附屬醫(yī)院內(nèi)分泌科;
【基金】：江蘇省衛(wèi)生和計劃生育委員會科技項目(Z201401)
【分類號】：R589.7
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