【摘要】：下一代基因測(cè)序技術(shù)是基因測(cè)序發(fā)展中的一項(xiàng)革命性的進(jìn)步,它在大幅度提高了測(cè)序通量的同時(shí)降低了測(cè)序成本。目前,下一代基因測(cè)序技術(shù)在臨床診斷及治療上的潛在應(yīng)用價(jià)值已成為研究熱點(diǎn)。惡性腫瘤的發(fā)病及預(yù)后與患者基因水平改變密切相關(guān),該技術(shù)應(yīng)用于臨床可以通過(guò)檢測(cè)個(gè)體基因改變,使惡性腫瘤的診斷和治療更具有針對(duì)性,從而推動(dòng)個(gè)體化治療的進(jìn)程。本綜述將闡述下一代基因測(cè)序技術(shù)在惡性腫瘤中的臨床應(yīng)用。
[Abstract]:The next generation gene sequencing technology is a revolutionary progress in the development of gene sequencing. It greatly increases the sequencing throughput and reduces the cost of sequencing. At present, the potential application value of next generation gene sequencing technology in clinical diagnosis and treatment has become a research hotspot. The pathogenesis and prognosis of malignant tumors are closely related to the changes of gene level of patients. The application of this technique in clinic can make the diagnosis and treatment of malignant tumors more targeted and promote the process of individualized treatment. This review will review the clinical application of next generation gene sequencing in malignant tumors.
【作者單位】： 天津醫(yī)科大學(xué)總醫(yī)院;
【基金】：天津市創(chuàng)新體系建設(shè)項(xiàng)目(No.07SYSY JC27900) 中瑞國(guó)際合作重點(diǎn)項(xiàng)目(天津市科技支撐計(jì)劃重點(diǎn)項(xiàng)目)(No.09ZCZDSF04100)資助
【分類號(hào)】：R730.4

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