本文選題：子癇前期 + CTLA基因　； 參考：《中國婦產(chǎn)科臨床雜志》2017年03期

【摘要】：目的探討CTLA4基因單核苷酸多態(tài)性位點rs231775與淮安地區(qū)漢族子癇前期發(fā)病風險的相關性。方法選擇2008年6月至2014年4月在江蘇省淮安市婦幼保健院產(chǎn)科住院分娩的子癇前期患者392例,選擇同期正常妊娠孕婦317例作為對照組,采用基質(zhì)輔助激光解吸附電離飛行時間質(zhì)譜對CTLA4基因rs231775位點進行基因分型。結(jié)果子癇前期組CTLA4基因rs231775多態(tài)性位點GG、AG和AA基因型頻率分別為53%,39%和8%,等位基因頻率G,A分別為72%和28%;而在對照組中GG、AG和AA頻率分別為45%,41%和14%,等位基因頻率G,A分別為65%和35%。經(jīng)卡方檢驗rs231775位點在兩組的基因型和等位基因頻率之間差異有統(tǒng)計學意義(P=0.025)。結(jié)論淮安地區(qū)的人群CTLA4基因rs231775位點的多態(tài)性與子癇前期有一定的關聯(lián)。
[Abstract]:Objective to investigate the association between CTLA4 gene single nucleotide polymorphism (rs231775) and preeclampsia risk in the Han nationality in Huaian area. Methods 392 cases of preeclampsia were selected from June 2008 to April 2014 in Huaian Maternal and Child Health Hospital of Jiangsu Province. 317 normal pregnant women were selected as control group. The rs231775 loci of CTLA4 gene were genotyped by matrix assisted laser desorption ionization time of flight mass spectrometry. Results in preeclampsia group, the frequencies of GGG AG and AA genotype of CTLA4 gene rs231775 polymorphism were 53 39% and 8%, respectively, and the allelic frequencies were 72% and 28%, respectively, while in the control group, the frequencies of GGG AG and AA were 4541% and 14%, respectively, and the frequencies of GGG AG and AA were 65% and 35%, respectively. The difference of genotype and allele frequency of rs231775 locus between the two groups was statistically significant by chi-square test. Conclusion the polymorphism of rs231775 locus of CTLA4 gene is associated with preeclampsia in Huaian area.
【作者單位】： 江蘇大學醫(yī)學院;揚州大學醫(yī)學院附屬淮安市婦幼保健院;
【基金】：江蘇省淮安市科技支撐計劃項目(HAS2010018,HAS2009003) 江蘇省衛(wèi)生廳婦幼保健重大科研項目(F201214) 淮安市科技創(chuàng)新載體平臺建設計劃項目(HAP201016)
【分類號】：R714.244

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