本文選題：胰腺炎 + 腫瘤壞死因子-α　； 參考：《重慶醫(yī)學(xué)》2017年27期

【摘要】：目的探討急性胰腺炎患者腫瘤壞死因子-α(TNF-α)基因多態(tài)性與患者病情嚴(yán)重程度及臨床預(yù)后的相關(guān)性。方法選取山東省醫(yī)學(xué)高等�？茖W(xué)校附屬醫(yī)院2015年6月至2016年6月確診的325例急性胰腺炎患者,采集外周血檢測(cè)TNF-α基因多態(tài)性,并用Balthazer CT嚴(yán)重指數(shù)(CTSI)評(píng)分和急性生理與慢性健康評(píng)分(APACHEⅡ)評(píng)價(jià)患者胰腺炎病情,根據(jù)患者APACHEⅡ評(píng)分進(jìn)行分組,7分的患者為觀察組,7分的患者為對(duì)照組,對(duì)比兩組患者CTSI評(píng)分、TNF-α基因表達(dá)情況,并采用Logistic回歸模型分析TNF-α基因多態(tài)性與急性胰腺炎預(yù)后的關(guān)系。結(jié)果觀察組96例患者A/A基因型為68例,占70.1%,CTSI評(píng)分為(8.3±0.4)分,明顯高于對(duì)照組患者,差異有統(tǒng)計(jì)學(xué)意義(P0.05),Logistic回歸分析結(jié)果提示APACHEⅡ評(píng)分上升3分(P=0.016)、TNF-α基因rs1800629位點(diǎn)基因型為A/A(P=0.04)、CTSI評(píng)分上升2分(P=0.012)均是患者預(yù)后不良的獨(dú)立危險(xiǎn)因素。結(jié)論 TNF-α基因多態(tài)性及CTSI評(píng)分與急性胰腺炎病情嚴(yán)重程度及臨床預(yù)后密切相關(guān)。
[Abstract]:Objective to investigate the relationship between tumor necrosis factor- 偽 (TNF- 偽) gene polymorphism and severity and clinical prognosis in patients with acute pancreatitis. Methods from June 2015 to June 2016, 325 patients with acute pancreatitis were selected from affiliated Hospital of Shandong Medical College, and peripheral blood samples were collected to detect the polymorphism of TNF- 偽 gene. The severity index of Balthazer CT and acute physiological and chronic health score (Apache 鈪，

本文編號(hào)：1911654