發(fā)布時間：2018-05-01 15:38

  本文選題：心房顫動 + SCN5A��； 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:心房顫動(房顫)是臨床上常見的房性心律失常,近幾年,SCN5A基因與房顫的關系受到高度關注,本文主要探討新疆地區(qū)維吾爾族,漢族心房顫動(atrial fibrillation AF)患者與SCN5A基因H558R位點多態(tài)性的關系。方法:以維吾爾族,漢族心房顫動患者各100例作為病例組,以維吾爾族,漢族非心房顫動患者各100例作為對照組,收集標本,提取外周血DNA,運用聚合酶鏈反應(PCR)及DNA測序技術檢測SCN5A基因H558R位點基因型及等位基因頻率。結果:維吾爾族房顫組基因型及等位基因的分布與非房顫組之間比較有顯著差異(P小于0.05),漢族房顫組基因型及等位基因的分布與非房顫組之間比較有顯著差異(P小于0.05),維吾爾族房顫患者與漢族房顫患者SCN5A基因H558R位點基因型頻率和等位基因頻率之間存在差異(P0.05),logistic回歸分析結果顯示G等位基因可能是房顫的一個易患基因(OR=2.189,95%CI=1.360-3.523,P=0.001)。結論:新疆地區(qū)維吾爾族,漢族心房顫動的發(fā)生可能與SCN5A基因H558R位點多態(tài)性相關,G等位基因可能是心房顫動遺傳易感性的獨立危險因子。SCN5A基因H558R位點多態(tài)性在漢族與維吾爾族房顫患者分布中存在民族差異,可能與各民族不同的遺傳因素,區(qū)域,生活習慣等有關。
[Abstract]:Objective: atrial fibrillation (AF) is a common atrial arrhythmia. In recent years, the relationship between SCN5A gene and atrial fibrillation is highly concerned. Relationship between polymorphism of H558R locus of SCN5A gene in patients with atrial fibrillation in Han nationality. Methods: 100 patients with atrial fibrillation in Uygur nationality and 100 patients with atrial fibrillation in Han nationality were selected as case group, 100 patients in Uygur nationality and 100 patients in Han nationality as control group. Polymerase chain reaction (PCR) and DNA sequencing were used to detect the genotype and allele frequency of H558R locus of SCN5A gene. Results: the distribution of genotypes and alleles in Uygur patients with atrial fibrillation was significantly different from that in non-atrial fibrillation patients (P < 0.05), and the distribution of genotypes and alleles in Han patients with atrial fibrillation was significantly different from that of non-atrial fibrillation patients (P < 0.05). The results of logistic regression analysis showed that G allele might be a susceptible gene of atrial fibrillation in Uygur patients with atrial fibrillation and Han nationality patients with atrial fibrillation. The results of logistic regression analysis showed that G allele might be a susceptible gene of atrial fibrillation, which was 1.360-3.523P0.001. Conclusion: Uygur people in Xinjiang, The occurrence of atrial fibrillation in Han nationality may be associated with the polymorphism of H558R locus of SCN5A gene. The allele G may be an independent risk factor of genetic susceptibility to atrial fibrillation .H558R locus polymorphism of SCN5A gene is distributed in patients with atrial fibrillation in Han and Uygur nationality. There are ethnic differences in China, May be related to different ethnic genetic factors, regions, habits and so on.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R541.75

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