本文選題：阻塞性睡眠呼吸暫停低通氣綜合征 + 瘦素受體�。� 參考：《中國呼吸與危重監(jiān)護雜志》2017年05期

【摘要】：目的探討西南地區(qū)漢族人群瘦素受體基因Gln223Arg多態(tài)性與阻塞性睡眠呼吸暫停低通氣綜合征(OSAHS)之間的關(guān)系。方法選取西南地區(qū)漢族人群215例(其中OSAHS組116例,健康對照組99例);用聚合酶鏈反應(yīng)(PCR)分析研究對象瘦素受體基因Gln223Arg多態(tài)性;雙抗體酶聯(lián)免疫吸附試驗(ELISA)法測定瘦素(LEP)、真胰島素(TI),同時測定體重指數(shù)(BMI)、頸圍(NC)、腰圍(WC)。結(jié)果 OSAHS組116例中,瘦素受體基因Gln223Arg多態(tài)性的GG、AA、GA的基因型頻率表達分別為0.854、0.017、0.129,G等位基因頻率為0.918;A等位基因頻率為0.082。對照組中,瘦素受體基因Gln223Arg多態(tài)性的GG、AA、GA的基因型頻率表達分別為0.840、0.020、0.14;G等位基因頻率為0.90;A等位基因頻率為0.10。兩組基因型頻率比較差異無統(tǒng)計學(xué)意義(X~2=0.784,P0.05)。Gln223Arg基因多態(tài)性的GG基因型OSAHS患者與(GA+AA)基因型OSAHS患者BMI、WC、NC比較差異有統(tǒng)計學(xué)意義(均P0.05)。對照組及輕、中、重度OSAHS組血清LEP、TI水平逐漸升高,各組間比較差異均有統(tǒng)計學(xué)意義(均P0.05)。結(jié)論瘦素受體基因型Gln223Arg多態(tài)性可能參與肥胖的發(fā)生,但與西南地區(qū)漢族人群OSAHS的發(fā)病無關(guān);OSAHS患者Gln223Arg多態(tài)性與LEP、TI無關(guān)。OSAHS患者存在高瘦素血癥、高胰島素血癥。
[Abstract]:Objective to investigate the relationship between leptin receptor gene Gln223Arg polymorphism and obstructive sleep apnea hypopnea syndrome (OSAHS). Methods the leptin receptor gene Gln223Arg polymorphism was analyzed by polymerase chain reaction (PCR) in 215 Han population in Southwest China (OSAHS group 116 cases and healthy control group 99 cases). The levels of leptin and insulin were determined by double antibody enzyme linked immunosorbent assay (Elisa), and the body mass index (BMI) was measured. Results in the OSAHS group, the genotypic frequencies of the Gln223Arg polymorphism of leptin receptor gene were 0.854, 0.017 and 0.129, respectively. The frequency of G allele was 0.918A and 0.082, respectively. In the control group, the genotypic frequencies of the Gln223Arg polymorphism of leptin receptor gene were 0.840 ~ 0.020 ~ (0.14) G allele and 0.90 ~ (0.90) A allele frequency, respectively. There was no significant difference in genotype frequency between the two groups. There was significant difference between the GG genotype OSAHS patients with GG genotype OSAHS and the GG genotype OSAHS patients (P 0.05). The level of serum LEP TI in the control group, mild, moderate and severe OSAHS group was increased gradually, and the difference was statistically significant among the groups (all P 0.05). Conclusion the Gln223Arg polymorphism of leptin receptor genotype may be involved in the development of obesity, but it is not related to the incidence of OSAHS in the Han nationality in Southwest China. The Gln223Arg polymorphism in OSAHS patients is not related to the leptin TI. There is hyperleptinemia and hyperinsulinemia in the patients with leptin receptor genotype.
【作者單位】： 貴陽市第六人民醫(yī)院急診科;貴州省人民醫(yī)院呼吸與危重醫(yī)學(xué)科;
【基金】：貴州省科技支撐計劃社會發(fā)展攻關(guān)項目(黔科合SY字[2009]3055)
【分類號】：R766

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