發(fā)布時間：2018-02-10 03:40

  本文關鍵詞： 骨缺損 基因治療 非病毒基因治療 生物支架　出處：《全科口腔醫(yī)學電子雜志》2016年13期 　論文類型：期刊論文

【摘要】：利用GBR技術修復口腔內骨缺損是目前臨床常用的方法,但骨移植材料單獨應用時其誘導成骨性能尚不能滿足所有臨床要求�；蛑委熓菍⒒騻魉椭寥睋p位點促進骨生成的一種組織工程學治療技術,按傳送方式不同分為病毒載體和非病毒載體基因治療,其中非病毒載體基因治療利用非病毒載體復合物轉染目標細胞促進其表達成骨蛋白。本文就非病毒載體基因治療載體的選擇,載體復合物的轉染,傳送工具以及向臨床轉換情況等做一綜述。
[Abstract]:It is a common clinical method to repair oral bone defect by using GBR technique. However, the osteogenic properties of bone grafts can not meet all the clinical requirements when they are used alone. Gene therapy is a kind of tissue engineering therapy which can transfer genes to defect sites to promote bone formation. It can be divided into viral vector and non-viral vector gene therapy according to the transmission mode. Non-viral vector gene therapy was used to transfect the target cells to promote the expression of osteogenic protein. In this paper, the selection of non-viral vector gene therapy vector, the transfection of vector complex, Transmission tools and the status of conversion to the clinic are reviewed.
【作者單位】： 山西醫(yī)科大學口腔醫(yī)學系;山西醫(yī)科大學第一醫(yī)院口腔科;
【分類號】：R782.4
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本文編號：1499570