本文關(guān)鍵詞：基于動態(tài)化學(xué)的自愈性水凝膠及其在生物醫(yī)用材料中的應(yīng)用研究展望，由筆耕文化傳播整理發(fā)布。

化 學(xué) 學(xué) 報(bào)

ACTA CHIMICA SINICA

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Review

DOI: 10.6023/A13010139

基于動態(tài)化學(xué)的自愈性水凝膠及其在生物醫(yī)用材料中的應(yīng)用研究展望

張亞玲 楊斌 許亮鑫 張小勇 陶磊* 危巖*

(清華大學(xué)化學(xué)系 北京100084)

摘要 自愈性材料具有自我修復(fù)損傷的特點(diǎn), 能夠增加使用材料的安全性, 延長材料壽命, 是一種具有損傷管理性能的智能新材料. 基于動態(tài)化學(xué)的自愈性水凝膠是近來備受關(guān)注的一種自愈性材料, 由具有動態(tài)特性的交聯(lián)網(wǎng)絡(luò)構(gòu)建形成. 交聯(lián)作用為動態(tài)化學(xué)鍵, 即非共價(jià)鍵, 如弱相互作用的氫鍵、分子間作用力(范德華力)、配位作用、親疏水作用等, 或可逆共價(jià)鍵, 如溫和條件下可逆的亞胺鍵、雙硫鍵、酰腙鍵等. 這種材料具有本征性的自愈性, 一方面可應(yīng)對外界破壞造成的損傷, 進(jìn)行自我修復(fù). 另一方面動態(tài)化學(xué)鍵對多種環(huán)境刺激具有響應(yīng)性, 能自我調(diào)節(jié)以適應(yīng)環(huán)境變化, 為將自愈性水凝膠開發(fā)為自適性多功能智能新材料奠定了基礎(chǔ). 水凝膠具有優(yōu)越的生物相容性以及和生物組織的相似性, 在生物醫(yī)用材料中如藥物控制釋放、組織工程修復(fù)、生物仿生等領(lǐng)域發(fā)揮著越來越大的作用, 而開發(fā)具有自愈性的多功能智能水凝膠, 將進(jìn)一步拓展其應(yīng)用. 綜述了近來基于動態(tài)化學(xué)的自愈性水凝膠的制備及其在生物醫(yī)用材料領(lǐng)域中的應(yīng)用研究.

關(guān)鍵詞 自愈性; 自適性; 水凝膠; 動態(tài)化學(xué); 智能軟物質(zhì)

Self-healing Hydrogels Based on Dynamic Chemistry and Their Bio-medical Applications

Zhang, Yaling Yang, Bin Xu, Liangxin Zhang, Xiaoyong Tao, Lei* Wei, Yen*

(Department of Chemistry, Tsinghua University, Beijing, 100084)

Abstract Self-healing materials are able to repair themselves automatically after external normal damages. This special property of self-healing materials could enhance the service life and ensure more safety while using such materials especially mechanically. Therefore, it has become a new emerging smart material which has the specialty to manage damages instead of traditional materials to avoid it. Self-healing hydrogels based on constitutional dynamic chemistry have received a lot of at-tentions recently with their intrinsic dynamic structures namely cross-linked polymer networks by dynamic bonds. Dynamic chemistry bonds contain both non-covalent bonds and reversible covalent bonds. Non-covalent bonds (weak effects) include hydrogen bonds, van der Waals forces, coordinative bonds, hydrophobic effects, etc. Reversible covalent bonds usually in-clude those chemistry bonds that could be reversible in mild conditions as imine bonds, disulfide bonds, acylhydrazone bonds and so on. Those hydrogels with dynamic cross-linked networks could not only manage external damages and repair them-selves as self-healing materials but also gain multi-responsive properties to environmental stimuli. The latter specialty comes from the adptive property of dynamic bonds to react to changes of reaction environments like pH, temperature and chemical reactants, thus building the foundation to develop self-healing hydrogels further into a multi-functional self-adaptive smart soft matter, which is of great significance for research to enrich multi-functional materials. Besides, hydrogel as a soft matter have long been vastly used in biomedical applications due to their superior biocompatibility and resemblance to biological tissues as mainly components (usually more than 70%) of hydrogel are water. They are playing a more and more important role in biomedical applications such as drug delivery systems, cell culture, tissue engineering and manmade biomimetic ma-terials. Developing multi-functional smart soft matter with self-healing property as self-healing hydrogels would be quite helpful to this emerging field with unexpected more biomedical materials. This paper reviews recent works about self-healing hydrogels based on dynamic chemistry and their future biomedical applications. Systems based on multiple-hydrogen bonds, coordination effects, hydrophobic effects, acylhydrazone bonds and imine bonds are specifically discussed. Keywords self-healing; self-adaptive; hydrogel; dynamic chemistry; smart soft matter

1 引言

眾所周知, 生物組織受損時(shí), 會有極為復(fù)雜而高效的自修復(fù)過程發(fā)生, 模仿此過程的新型材料即為備受關(guān)

注的自愈性材料. 自愈性材料的開發(fā)可以提高相關(guān)材料使用的安全性, 延長材料的使用壽命等, 在近10年來的研究中受到了越來越多的關(guān)注[1～4].

由于高分子材料具有可調(diào)節(jié)的化學(xué)結(jié)構(gòu)和機(jī)械性

* E-mail: leitao@; weiyen@; Tel.: 010-62792604; Fax: 010-62794694

Received January 28, 2013; published March 5, 2013.

Project supported by the National Natural Science Foundation of China (Nos. 21104039, 21134004) and the National 973 Project (No. 2011CB935700). 項(xiàng)目受國家自然科學(xué)基金(Nos. 21104039, 21134004)及國家973項(xiàng)目(No. 2011CB935700)資助. Acta Chim. Sinica 2013, 71, 485—492 © 2013 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 485

  本文關(guān)鍵詞：基于動態(tài)化學(xué)的自愈性水凝膠及其在生物醫(yī)用材料中的應(yīng)用研究展望，由筆耕文化傳播整理發(fā)布。