本文選題：布洛芬 + 控制釋放��； 參考：《南華大學(xué)》2015年碩士論文

【摘要】：布洛芬是世界普遍公認(rèn)的非甾體解熱鎮(zhèn)痛藥,而控制釋放系統(tǒng)可以最大限度地發(fā)揮其在人體內(nèi)的藥物活性,并減少給藥劑量。早期合成的介孔材料孔道不規(guī)則,孔徑分布不均勻,使其在藥物控制釋放方面的應(yīng)用受到了很大程度地限制。采用凝膠-溶膠法合成的MCM-41介孔硅材料具有更多的孔洞特性和微粒形態(tài),其孔內(nèi)可以負(fù)載藥物分子,表面可以通過(guò)改性組裝功能性分子;并通過(guò)不同的外來(lái)刺激影響其表面理化性質(zhì)以控制功能分子對(duì)二氧化硅孔洞的打開(kāi)和閉合,進(jìn)而實(shí)現(xiàn)控制釋放孔洞中藥物分子的目的。本文采用凝膠-溶膠法并添加有機(jī)擴(kuò)孔劑,制備了MCM-41與MCM-41-Epoxy兩種介孔二氧化硅材料,以制得的介孔二氧化硅為載體,進(jìn)行介孔二氧化硅對(duì)布洛芬控制釋放的比較研究。具體研究?jī)?nèi)容如下:(1)介孔二氧化硅材料的合成與表征。堿性條件下,用CTAB(十六烷基三甲基溴化銨)作為模板劑與TEOS(正硅酸乙酯)發(fā)生反應(yīng),加入1,3,5-三甲苯擴(kuò)孔,反應(yīng)完成后采用酸洗法去除模板,制備了具有較大孔徑的MCM-41介孔硅材料。在此基礎(chǔ)上,將制得的MCM-41環(huán)氧基功能化。以無(wú)水甲苯為反應(yīng)介質(zhì),將MCM-41與硅烷偶聯(lián)劑KH560(γ-縮水甘油醚氧丙基三甲氧基硅烷)高溫反應(yīng),制備了環(huán)氧基功能化的MCM-41-Epoxy材料。將兩種材料進(jìn)行紅外、掃描電鏡、X射線粉末衍射、氮?dú)馕矫摳降纫幌盗斜碚?結(jié)果表明,環(huán)氧基的特征峰在910cm-1附近,MCM-41材料比表面積(SBET)、孔容V/(cm3.g-1)以及孔徑(D/nm)、XRD的衍射峰值均大于MCM-41-Epoxy。(2)負(fù)載布洛芬及其控制釋放的研究。將兩種材料放入高濃度的布洛芬溶液中充分吸附,直至溶液的紫外吸收吸光度不再發(fā)生變化。計(jì)算出MCM-41與MCM-41-Epoxy兩種介孔材料對(duì)布洛芬的負(fù)載率,分別為18.92%和27.36%。通過(guò)模擬兩種人體體液p H環(huán)境對(duì)MCM-41-Epoxy-IBU中布洛芬釋放率的研究,最終選擇p H為7.4的PBS緩沖溶液作為應(yīng)激物,構(gòu)建控釋系統(tǒng)。經(jīng)比較研究,MCM-41對(duì)布洛芬的釋放速度較快,經(jīng)約9h釋放量達(dá)到80%以上。而MCM-41-Epoxy釋放較緩慢,24h后達(dá)到65%左右的釋放量。
[Abstract]:Ibuprofen is widely recognized as a nonsteroidal antipyretic analgesics, and the controlled release system can maximize its drug activity in human body and reduce the dosage of the drug. The irregular pore channels and uneven pore size distribution of the early synthesized mesoporous materials limited their application in drug controlled release to a large extent. The MCM-41 mesoporous silicon materials synthesized by gel-sol method have more pore characteristics and particle morphology, which can be loaded with drug molecules in their pores, and functional molecules can be assembled on the surface by modification. In order to control the opening and closing of Sio _ 2 pores by different external stimuli, the surface physicochemical properties can be controlled, and the aim of controlling the release of drug molecules in the pores can be achieved. In this paper, two kinds of mesoporous silica materials, MCM-41 and MCM-41-Epoxy, were prepared by gel-sol method and organic reaming agent. The controlled release of ibuprofen from mesoporous silica was studied by using mesoporous silica as carrier. The main contents are as follows: 1) Synthesis and characterization of mesoporous silica. In alkaline condition, CTAB (cetyltrimethylammonium bromide) was used as template agent to react with TEOS (ethyl orthosilicate), adding 1k3ttrimethylbenzene to dilatate the pores. After the reaction was finished, the template was removed by acid washing method. MCM-41 mesoporous silicon with large pore size was prepared. On this basis, the MCM-41 epoxy group was functionalized. Epoxy functional MCM-41-Epoxy materials were prepared by high temperature reaction of MCM-41 with silane coupling agent KH 560 (緯 -glycidyl propyl trimethoxysilane) in anhydrous toluene as reaction medium. Two kinds of materials were characterized by IR, SEM X-ray powder diffraction, nitrogen adsorption and desorption. The specific surface area of MCM-41 material near 910cm-1, the pore volume V / P cm3.g-1) and the peak diffraction peak of the pore size D / N ~ (-1) are all larger than those of MCM-41-Epoxy.P-2) loaded ibuprofen and their controlled release. The two materials were fully adsorbed in a high concentration ibuprofen solution until the UV absorbance of the solution was no longer changed. The loading rates of two mesoporous materials, MCM-41 and MCM-41-Epoxy, for ibuprofen were 18.92% and 27.36, respectively. The release rate of ibuprofen in MCM-41-Epoxy-IBU was studied by simulating two kinds of human body fluid pH environment. Finally, PBS buffer solution with pH 7.4 was selected as stress substance to construct controlled release system. The release rate of ibuprofen by MCM-41 was faster than that of MCM-41, and the release rate of ibuprofen reached more than 80% after about 9 hours. However, the release of MCM-41-Epoxy was about 65% after 24 hours of release.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類(lèi)號(hào)】：TQ460.1;TQ127.2

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本文編號(hào)：1808270