碰撞氣體的種類和壓力對離子阱質譜性能的影響
發(fā)布時間：2018-09-13 07:56
【摘要】：基于數(shù)字離子阱技術,研究了離子阱質譜分析實驗過程使用的碰撞氣體種類及壓力對離子阱質譜性能,如質量分辨能力、信號強度、串級質譜分析,以及低質量截止效應等的影響。實驗過程中,在離子的激發(fā)和碰撞誘導解離階段,分別采用質量數(shù)不等的氦氣(質量數(shù)=4 amu)、氮氣(質量數(shù)=28 amu)、氬氣(質量數(shù)=40 amu)等作為碰撞氣體,以及不同的氣體壓力,研究了它們對質譜性能的影響。結果表明,當采用質量數(shù)較大的氬氣作為碰撞氣體時,可以有效改善低質量數(shù)截止效應和提高離子碰撞過程中的能量轉移效率,同時提高離子捕獲和解離效率,但是質量分辨率會明顯降低。在獲得較高質量分辨率方面,氦氣作為碰撞氣體時效果最好。在氣壓相同的情況下,質量數(shù)大的碰撞氣體有利于提高串級質譜分析效率,即獲得更多碎片離子峰和更多有關母體離子結構的信息。
[Abstract]:Based on the digital ion trap technique, the types of collisional gases used in ion trap mass spectrometry analysis and the performance of pressure on ion trap mass spectrometry, such as mass resolution, signal intensity, cascade mass spectrometry analysis, are studied. And the effect of low quality cutoff effect. In the process of ion excitation and collision induced dissociation, helium (mass number 4 amu), nitrogen) (mass number 28 amu), argon (mass number 40 amu) was used as collision gas, and different gas pressures were used, respectively, in the process of ion excitation and collision-induced dissociation, respectively, with different mass numbers of helium (mass number of 4 amu), nitrogen gas) and mass number of 28 amu), argon (mass number of 40 amu). Their effects on the mass spectrum properties were studied. The results show that the low mass cut-off effect, energy transfer efficiency and ion capture and dissociation efficiency can be improved effectively when argon gas with large mass number is used as collision gas. But the mass resolution is significantly reduced. Helium is the most effective as collision gas in obtaining high mass resolution. Under the same pressure, the collision gas with large mass can improve the efficiency of cascade mass spectrometry, that is to say, more fragment ion peaks and more information about the structure of parent ions can be obtained.
【作者單位】： 復旦大學電子工程系;復旦大學化學系激光化學研究所;廣州禾信儀器股份有限公司;
【基金】：科技部十二五重大科學儀器設備開發(fā)專項(No.2011YQ14015006)資助~~
【分類號】：O657.63
[Abstract]:Based on the digital ion trap technique, the types of collisional gases used in ion trap mass spectrometry analysis and the performance of pressure on ion trap mass spectrometry, such as mass resolution, signal intensity, cascade mass spectrometry analysis, are studied. And the effect of low quality cutoff effect. In the process of ion excitation and collision induced dissociation, helium (mass number 4 amu), nitrogen) (mass number 28 amu), argon (mass number 40 amu) was used as collision gas, and different gas pressures were used, respectively, in the process of ion excitation and collision-induced dissociation, respectively, with different mass numbers of helium (mass number of 4 amu), nitrogen gas) and mass number of 28 amu), argon (mass number of 40 amu). Their effects on the mass spectrum properties were studied. The results show that the low mass cut-off effect, energy transfer efficiency and ion capture and dissociation efficiency can be improved effectively when argon gas with large mass number is used as collision gas. But the mass resolution is significantly reduced. Helium is the most effective as collision gas in obtaining high mass resolution. Under the same pressure, the collision gas with large mass can improve the efficiency of cascade mass spectrometry, that is to say, more fragment ion peaks and more information about the structure of parent ions can be obtained.
【作者單位】： 復旦大學電子工程系;復旦大學化學系激光化學研究所;廣州禾信儀器股份有限公司;
【基金】：科技部十二五重大科學儀器設備開發(fā)專項(No.2011YQ14015006)資助~~
【分類號】：O657.63
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