【摘要】：自從表面增強(qiáng)拉曼散射(SERS)被發(fā)現(xiàn)以來(lái),SERS光譜技術(shù)因其高靈敏、快速、高效、簡(jiǎn)單的優(yōu)點(diǎn)被廣泛應(yīng)用于生物、醫(yī)學(xué)、化學(xué)分析等領(lǐng)域。特別是當(dāng)目標(biāo)分子數(shù)量低于ppb級(jí)別時(shí),SERS光譜的優(yōu)勢(shì)顯得尤為突出,它可以在復(fù)雜的體系中檢測(cè)到生物化學(xué)類樣品的指紋特征拉曼譜,可用于檢測(cè)、鑒定甚至標(biāo)定含量。近年來(lái)我國(guó)的食品安全問(wèn)題時(shí)有發(fā)生,簡(jiǎn)單高效的SERS光譜技術(shù)在食品安全檢測(cè)中發(fā)揮了重要的作用。將SERS技術(shù)應(yīng)用于食品安全檢測(cè)最關(guān)鍵的是制備出經(jīng)濟(jì)、增強(qiáng)效果好、可重復(fù)性高的SERS襯底。本論文利用FDTD方法對(duì)金字塔、截角金字塔、橢球體、方塊、米字形和點(diǎn)陣形貌金襯底的散射光譜和空間電場(chǎng)分布進(jìn)行了理論模擬計(jì)算,分析了襯底的表面等離子體共振特性,研究了各自的SERS效果。模擬結(jié)果表明將襯底表面微形貌化會(huì)產(chǎn)生較好的增強(qiáng)效果,并且復(fù)雜的形貌比單一的形貌增強(qiáng)效果更好,同時(shí)形貌的尺寸改變時(shí),散射光譜的規(guī)律也會(huì)發(fā)生變化。實(shí)驗(yàn)中利用電子束曝光和軟模板壓印技術(shù)成功制備出了米字形和點(diǎn)陣形貌的金襯底,并將其用于胱氨酸和三聚氰胺的拉曼散射光譜的測(cè)量,測(cè)量結(jié)果表明米字形金襯底和點(diǎn)陣金襯底都能檢測(cè)到濃度為50ppm的胱氨酸的拉曼特征峰,并且米字形金襯底也可以檢測(cè)到濃度為50ppm的三聚氰胺的拉曼特征峰。
[Abstract]:Since the discovery of surface-enhanced Raman scattering (SERS) spectroscopy technology has been widely used in biological, medical, chemical analysis and other fields because of its high sensitivity, fast, high efficiency and simple advantages. Especially when the number of target molecules is lower than the ppb level, the advantage of SERS spectrum is particularly obvious. It can detect the characteristic Raman spectrum of biochemistry samples in complex system, and can be used to detect, identify and even calibrate the content. In recent years, food safety problems occur from time to time in our country. Simple and efficient SERS spectrum technology plays an important role in food safety detection. The key to the application of SERS in food safety detection is to prepare SERS substrates which are economical, effective and reproducible. In this paper, the scattering spectra and spatial electric field distribution of gold substrates with pyramid, truncated pyramid, ellipsoid, block, meter shape and lattice topography are simulated by FDTD method. The surface plasmon resonance characteristics of the substrate are analyzed. The effects of SERS were studied. The simulation results show that the microtopography of the substrate surface will produce a better enhancement effect, and the complex morphology is better than the single morphology enhancement effect. At the same time, when the size of the morphology changes, the law of the scattering spectrum will also change. In the experiment, the gold substrates with meter shape and lattice morphology were successfully prepared by electron beam exposure and soft template imprint techniques, and used to measure the Raman scattering spectra of cystine and melamine. The results show that the Raman characteristic peaks of cystine at the concentration of 50ppm can be detected on the meter shaped gold substrate and the lattice gold substrate, and the Raman characteristic peak of melamine at the concentration of 50ppm can also be detected on the meter shaped gold substrate.
【學(xué)位授予單位】：南京郵電大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O657.37

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