本文選題：氮雜環(huán)卡賓 + Strecker反應(yīng)��； 參考：《有機(jī)化學(xué)》2017年04期

【摘要】：以四氫呋喃為溶劑,氮雜環(huán)卡賓為催化劑,進(jìn)行了氰基甲酸乙酯和亞胺的Strecker反應(yīng)研究.實(shí)驗(yàn)中考察了催化劑的種類、用量及溶劑對(duì)反應(yīng)的影響,確定了最優(yōu)反應(yīng)條件.結(jié)果顯示氰基甲酸乙酯與芳香亞胺、脂肪亞胺都能發(fā)生Strecker反應(yīng),最終合成了14個(gè)α-氨基腈衍生物,產(chǎn)物產(chǎn)率最高達(dá)到93%.該反應(yīng)具有操作簡(jiǎn)單,條件溫和,產(chǎn)率高及環(huán)境友好等優(yōu)點(diǎn).
[Abstract]:The Strecker reaction of ethyl cyanate and imine was studied using tetrahydrofuran as solvent and heterocyclic carbene as catalyst. The effects of catalyst type, dosage and solvent on the reaction were investigated, and the optimum reaction conditions were determined. The results showed that 14 偽 -aminonitrile derivatives were synthesized by Strecker reaction of ethyl cyanate with aromatic imines and aliphatic imines. The highest yield of the products was 933%. The reaction has the advantages of simple operation, mild conditions, high yield and environmental friendliness.
【作者單位】： 石河子大學(xué)化學(xué)化工學(xué)院新疆兵團(tuán)化工綠色過(guò)程重點(diǎn)實(shí)驗(yàn)室-省部共建國(guó)家重點(diǎn)實(shí)驗(yàn)室培育基地;
【基金】：國(guó)家自然科學(xué)基金(No.21262027)資助項(xiàng)目~~
【分類號(hào)】：O621.251
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本文編號(hào)：2060205