本文選題：SERS基底　切入點：自組裝膜　出處：《寧波大學》2017年碩士論文

【摘要】：表面增強拉曼散射(SERS)現(xiàn)象能夠將粗糙金屬表面附近的分子的拉曼信號增加104~106倍,彌補了拉曼光譜靈敏度低的缺點,其應用依賴于SERS基底,因此發(fā)展新型SERS基底一直以來都是SERS研究領域的熱點。本論文圍繞SERS基底的制備和應用,開展以下工作:1.制備了具有球狀結構的Ag納米顆粒自組裝膜的SERS基底,首先在硅片表面自組裝上單層SiO_2@Au納米粒子,然后通過無電沉積法在納米粒子的表面快速生長一層銀殼獲得SiO_2@Au@Ag膜。我們以4-巰基吡啶為探針分子,檢測限可達到10-11 M,拉曼增強因子為2.6×107,而對于單顆包裹Ag納米顆粒的球狀SiO_2粒子來說,其拉曼的檢測限只有10-8M,兩者的對比展示了包裹銀顆粒的自組膜具有明顯的SERS增強優(yōu)勢。然后我們將SiO_2@Au@Ag膜作為基底,檢測水果表面農(nóng)藥的殘留。只需將SiO_2@Au@Ag膜基底輕輕地在蘋果表面一擦,即可進行拉曼檢測,操作方便,快捷且靈敏度高。2.將分子印跡技術和表面增強拉曼技術相結合,制備了氧化石墨烯/分子印跡聚合物-探針分子-銀納米顆粒的三明治結構。在三明治結構中,氧化石墨烯為分子印跡聚合物提供了良好的結合位點,而分子印跡聚合物因其鑰匙-鎖的獨特結構對模板分子進行選擇性的吸附,而附著在上面的銀納米顆粒起到了SERS增強的作用。這種三明治結構具有良好的SERS性能和抗干擾性和選擇性吸附,使用此結構對模板分子進行拉曼檢測,其檢測限可達到10-11 M,同時將模板分子與其他類似物進行混合時,三明治結構對模板分子進行選擇性吸附,抗干擾性顯著。
[Abstract]:The surface-enhanced Raman scattering (SERS) phenomenon can increase the Raman signal of the molecules near the rough metal surface by 104 ~ 106-fold, which makes up for the low sensitivity of the Raman spectrum, and its application depends on the SERS substrate.Therefore, the development of new SERS substrate has always been a hot spot in the field of SERS research.In this paper, we focus on the preparation and application of SERS substrate, and do the following work: 1.The SERS substrate of Ag nanoparticles self-assembled film with spherical structure was prepared. Firstly, monolayer SiO_2@Au nanoparticles were self-assembled on the surface of silicon wafer, and then a layer of silver shell was rapidly grown on the surface of nano-particles by electrodeposition without electrodeposition to obtain SiO_2@Au@Ag film.Using 4-mercaptopyridine as the probe molecule, the detection limit can reach 10-11 Mand the Raman enhancement factor is 2.6 脳 10 ~ 7. For a single spherical SiO_2 particle coated with Ag nanoparticles, the detection limit is 10 ~ (-11) M, and the Raman enhancement factor is 2.6 脳 10 ~ (7).The Raman detection limit is only 10 ~ (-8) M.The comparison of the two shows that the self-assembled films coated with silver particles have obvious SERS enhancement advantages.Then the SiO_2@Au@Ag membrane was used as the substrate to detect pesticide residues on the fruit surface.As long as the substrate of SiO_2@Au@Ag film is lightly rubbed on the surface of apple, Raman detection can be carried out, which is convenient, quick and sensitive.The sandwich structure of graphene oxide / molecularly imprinted polymer probe molecular silver nanoparticles was prepared by combining molecular imprinting technique with surface-enhanced Raman technique.In sandwich structure, graphene oxide provides a good binding site for molecularly imprinted polymers, while molecular imprinted polymers selectively adsorb template molecules because of their unique key- lock structure.On the other hand, the silver nanoparticles attached to it play a role in the enhancement of SERS.The sandwich structure has good SERS performance, anti-interference and selective adsorption. The Raman detection limit of the template molecule can reach 10-11 Mwhen the template molecule is mixed with other analogues.Sandwich structure can selectively adsorb template molecule, and the anti-interference property is obvious.
【學位授予單位】：寧波大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：O657.37

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