本文選題：方法學驗證　切入點：拉曼光譜法　出處：《光譜學與光譜分析》2017年01期

【摘要】：拉曼光譜在中國藥典2010版第一次被收錄于"附錄XIX L拉曼光譜法指導(dǎo)原則"中,但該原則對拉曼多組分定量分析的方法學驗證未作論述,對多組分復(fù)雜體系中采用拉曼數(shù)學模型定量分析時的方法學驗證進行獨創(chuàng)性的探索和研究,分別從儀器性能測試、線性、定量限、準確度等方面進行方法學驗證研究;另外由于拉曼光譜定量數(shù)學模型樣品為復(fù)雜成分樣品,無須像傳統(tǒng)方法提供空白樣品和進行破壞實驗等專屬性實驗驗證。通過研究探討,提出了拉曼多組分定量分析的方法學驗證內(nèi)容,為方法學驗證的完善和標準的制定提供了基礎(chǔ)和依據(jù)。
[Abstract]:Raman spectroscopy was first included in the guidelines of XIX L Raman Spectrometry in Chinese Pharmacopoeia 2010. However, this principle did not discuss the methodological verification of quantitative analysis of Raman multicomponent.Original exploration and research on the methodology verification of quantitative analysis by Raman mathematical model in multicomponent complex system are carried out respectively from the aspects of instrument performance test linearity quantitative limit accuracy and so on.In addition, because the sample of quantitative mathematical model of Raman spectrum is a sample of complex components, it is not necessary to provide blank samples as traditional methods and to carry out specific experiments such as destruction experiments.The content of methodology verification of Raman multicomponent quantitative analysis is put forward, which provides the basis and basis for the perfection of methodology verification and the formulation of standards.
【作者單位】： 新鄉(xiāng)醫(yī)學院藥學院;四川大學華西藥學院;新鄉(xiāng)醫(yī)學院三全學院藥學院;成都中醫(yī)藥大學藥學院;
【基金】：國家自然科學基金面上項目(81373969) 河南省高等學校重點科研項目(17A360026) 新鄉(xiāng)醫(yī)學院博士科研啟動基金項目(505095)
【分類號】：O657.37

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