發(fā)布時間：2018-01-03 15:10

  本文關(guān)鍵詞：基于漫反射光譜的組織光學(xué)參數(shù)測量系統(tǒng)與方法研究　出處：《光譜學(xué)與光譜分析》2016年05期 　論文類型：期刊論文

  更多相關(guān)文章： 組織光學(xué)參數(shù) 漫反射光譜 光纖探頭 單一源探距離 主成分分析

【摘要】：在體組織光學(xué)參數(shù)測量是生物醫(yī)學(xué)光子學(xué)研究重點,不僅為人體成分無創(chuàng)檢測、光學(xué)成像、光動力療法等研究提供基礎(chǔ),并且可以快速獲取人體光學(xué)參數(shù)變化,為臨床診斷提供依據(jù)。研究了利用單一源探距離漫反射光譜在體測量光學(xué)參數(shù)的測量系統(tǒng)與反構(gòu)方法。漫反射光譜測量系統(tǒng)由寬譜光源、高分辨光纖光譜儀及光纖探頭組成,結(jié)構(gòu)簡單,測量方便,可準(zhǔn)確快速測量樣品漫反射光譜。在光纖探頭幾何形狀基礎(chǔ)上,研究了光纖收集及系統(tǒng)傳遞函數(shù),在此基礎(chǔ)上對反構(gòu)算法進(jìn)行了校正。光學(xué)參數(shù)反構(gòu)算法中正向模型基于Monte Carlo以及神經(jīng)網(wǎng)絡(luò)方法,適用光學(xué)參數(shù)范圍大,計算速度快;逆向算法采用主成分分析與非線性建模擬合相結(jié)合的方法,可抑制測量噪聲影響。在測量系統(tǒng)及反構(gòu)算法基礎(chǔ)上,進(jìn)行了組織仿體光學(xué)參數(shù)測量實驗,結(jié)果表明,利用單一源探距離下漫反射譜,可以較為準(zhǔn)確獲取吸收系數(shù)以及約化散射系數(shù),均方根誤差分別達(dá)到4.58%以及7.92%。為保證系統(tǒng)測量準(zhǔn)確性,測量波長范圍應(yīng)覆蓋樣品中所含吸收物質(zhì)吸收峰范圍。所研究的在體組織光學(xué)參數(shù)測量方法為人體成分無創(chuàng)檢測及測量條件變化獲取提供了基礎(chǔ)。
[Abstract]:The measurement of in vivo tissue optical parameters is the focus of biomedical photonics. It not only provides the basis for the study of human component noninvasive detection, optical imaging, photodynamic therapy, but also can quickly obtain the changes of human optical parameters. To provide the basis for clinical diagnosis. The measurement system and the inversion method of in vivo measurement of optical parameters using single source probe range diffuse reflectance spectroscopy are studied. The diffuse reflectance spectrum measurement system is based on a wide spectrum light source. The high resolution optical fiber spectrometer and the optical fiber probe are composed of simple structure and convenient measurement. Based on the geometrical shape of the optical fiber probe, the optical fiber collection and the system transfer function are studied. The forward model of optical parameter inversion algorithm is based on Monte Carlo and neural network method, which is suitable for a wide range of optical parameters and fast calculation speed. The inverse algorithm combines principal component analysis (PCA) with nonlinear modeling and fitting to suppress the influence of measurement noise. On the basis of the measurement system and the inverse algorithm, the measurement experiments of the optical parameters of tissue simulation are carried out. The results show that the absorption coefficient and the reduced scattering coefficient can be obtained more accurately by using the diffuse reflectance spectrum at a single source. The root mean square error is 4.58% and 7.92 respectively. The measurement wavelength range should cover the absorption peak range of the absorbent material contained in the sample. The optical parameter measurement method in vivo provides the basis for the noninvasive detection of human components and the acquisition of the change of measurement conditions.
【作者單位】： 天津大學(xué)精密測試技術(shù)及儀器國家重點實驗室;天津大學(xué)精密儀器與光電子工程學(xué)院;
【基金】：國家(863)高技術(shù)研究發(fā)展計劃項目(2012AA022602) 國家自然科學(xué)基金項目(81401454,81471698) 中國博士后科學(xué)基金項目(2013M541174) 中國博士后國際交流計劃(20140066)資助
【分類號】：O657.33
【正文快照】： 引言隨著光譜檢測技術(shù)及儀器的發(fā)展,基于人體光譜測量的組織成分檢測及成像診斷研究逐漸成為生物醫(yī)學(xué)光學(xué)研究熱點。人體組織光學(xué)特性,如吸收系數(shù)、散射系數(shù)變化與其生理病理狀態(tài)密切相關(guān),為腫瘤早期診斷、代謝動態(tài)監(jiān)護(hù)及光動力治療等臨床應(yīng)用提供了基礎(chǔ)[1-5]。人體組織光學(xué)參，

本文編號：1374410