【摘要】：光誘導(dǎo)介電泳是基于介電泳基礎(chǔ)上發(fā)展出來的一種新型微粒操縱技術(shù)，相對于傳統(tǒng)的介電泳操縱，光電子鑷最大的特點(diǎn)是可靈活操控的虛擬電極，通過軟件控制可以在光電導(dǎo)層的任意位置形成需要的光學(xué)圖案從而達(dá)成靈活的操縱效果。光誘導(dǎo)介電泳對微粒的無接觸、無損傷的操縱，在生物科學(xué)、醫(yī)學(xué)、藥理學(xué)領(lǐng)域具有廣泛的應(yīng)用前景。 本文首先詳細(xì)介紹了不同類型微納操縱手段的理論與優(yōu)缺點(diǎn)，隨后介紹了光誘導(dǎo)介電泳的研究進(jìn)展和在微納操縱方面的應(yīng)用，還對光誘導(dǎo)介電泳的理論進(jìn)行了分析，在理論上推導(dǎo)了介電泳的操縱機(jī)制，，并使用COMSOL和MATLAB軟件對其進(jìn)行了分析，同時詳述了光電導(dǎo)層的材料—非晶硅薄膜的結(jié)構(gòu)、性能和常用制備方法。為后期淀積實驗選擇的合理參數(shù)提供了理論基礎(chǔ)。最后對細(xì)胞的介電泳操縱進(jìn)行研究，介紹了細(xì)胞的介電模型，和常用的介電分析方法。 在實驗部分，首先是對光電導(dǎo)層的淀積實驗，根據(jù)實際情況設(shè)定合適的參數(shù)，通過對淀積結(jié)果的測試，得出最優(yōu)的一組參數(shù)。最后進(jìn)行了試驗臺的搭建，設(shè)計了光誘導(dǎo)介電泳芯片，通過激發(fā)光電導(dǎo)層的光電效應(yīng)形成虛擬電極，同時施加高頻交流電壓，實現(xiàn)了對4μm和10μm聚苯乙烯微球的介電泳力操縱。最終微球在負(fù)介電泳力的作用下分別以8.8μm/s和35μm/s的速度運(yùn)動。通過光誘導(dǎo)介電泳實現(xiàn)了對微球的無接觸無損傷的操縱。
[Abstract]:Photoinduced electrophoresis is a new particle manipulation technology based on dielectric electrophoresis. Compared with the traditional dielectric electrophoresis manipulation, optoelectronic tweezers are characterized by flexible virtual electrodes. The desired optical pattern can be formed at any position of the photoconductive layer by software control, so as to achieve flexible manipulation effect. Photoinduced electrophoresis has a wide range of application prospects in bioscience, medicine and pharmacology because of its non-contact and non-invasive manipulation of particles. In this paper, the theories, advantages and disadvantages of different types of micro-nano manipulation methods are introduced in detail, and then the research progress and application of photoinduced dielectric electrophoresis in micro-nano manipulation are introduced in detail, and the theory of photoinduced dielectric electrophoresis is also analyzed. The manipulation mechanism of dielectric electrophoresis is deduced theoretically and analyzed by COMSOL and MATLAB software. At the same time, the structure, properties and common preparation methods of amorphous silicon thin films, which are the materials of photoconductive layer, are described in detail. It provides a theoretical basis for the selection of reasonable parameters in the later deposition experiment. Finally, the manipulation of cell dielectric electrophoresis was studied, and the dielectric model of cells and the commonly used dielectric analysis methods were introduced. In the experimental part, first of all, the deposition experiment of the photoconductive layer is carried out, and the appropriate parameters are set according to the actual situation. Through the test of the deposition results, the optimal set of parameters is obtained. Finally, the test-bed is built, and the photoinduced dielectric electrophoresis chip is designed. The virtual electrode is formed by stimulating the photoelectric effect of the photoconductive layer, and the dielectric swimming force of 4 渭 m and 10 渭 m polystyrene microspheres is manipulated by applying high frequency AC voltage. Finally, the microspheres moved at the speeds of 8.8 渭 m / s and 35 渭 m / s, respectively, under the action of negative dielectric electrophoresis. The non-contact and damage-free manipulation of microspheres was realized by photoinduced electrophoresis.
【學(xué)位授予單位】：中北大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TN492

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