【摘要】：介孔磁性普魯士藍(lán)是很好的納米醫(yī)藥材料,但目前仍缺少合成這種材料的有效方法,這里我們采用配位復(fù)制以及自上而下刻蝕的一鍋反應(yīng)的方法分別以Fe_3O_4為核,得到介孔磁性蛋殼結(jié)構(gòu)Fe_3O_4@PB,不同反應(yīng)時間的掃描圖表明PB晶體在質(zhì)子作用下在Fe_3O_4表面成核并生長,溶液中多余的質(zhì)子進(jìn)一步腐蝕Fe_3O_4及PB得到介孔結(jié)構(gòu),最后推廣此合成方法,以NiFe2O4為核,合成多孔磁性蛋殼結(jié)構(gòu)NiFe2O4@Ni-FePBA。通過在DMF和水的混合溶劑中,配位復(fù)制及控制刻蝕的方法合成了多孔核殼Fe_3O_4@片狀PB復(fù)合材料,并采用同樣的方法制備了多孔核殼NiFe2O4@Ni-FePBA復(fù)合物,產(chǎn)物均為球形核殼結(jié)構(gòu),殼層為片狀普魯士藍(lán)類配合物分級結(jié)構(gòu)組裝。我們將所合成的介孔蛋殼結(jié)構(gòu)Fe_3O_4@PB磁性復(fù)合物應(yīng)用與多功能納米醫(yī)藥應(yīng)用中,介孔蛋殼結(jié)構(gòu)Fe_3O_4@PB可以有效負(fù)載藥物順鉑,并表現(xiàn)溫度敏感釋藥,對磁場或者紅外激光都可以響應(yīng)釋放熱量,合成的介孔蛋殼結(jié)構(gòu)Fe_3O_4@PB材料可以有效負(fù)載藥物并殺死癌細(xì)胞。
[Abstract]:The mesoporous magnetic Prussian blue is a good nanometer medical material, but there is still no effective method to synthesize this material. Here we use coordination replication and top-down etching one-pot reaction method to use Fe_3O_4 as the core, respectively. Scanning images of mesoporous magnetic eggshell Fe_3O_4@PB, at different reaction times show that PB crystals nucleate and grow on the surface of Fe_3O_4 under the action of protons, and superfluous protons in solution further corrode Fe_3O_4 and PB to obtain mesoporous structures. Synthesis of porous magnetic eggshell NiFe2O4@Ni-FePBA. with NiFe2O4 as core The porous core-shell Fe_3O_4@ lamellar PB composites were synthesized by coordination replication and etching control in the mixed solvent of DMF and water. The porous core-shell NiFe2O4@Ni-FePBA composites were prepared by the same method. The products were spherical core-shell structure. The shell is composed of flake Prussian blue complexes with hierarchical structure. In the application of the synthesized mesoporous Fe_3O_4@PB magnetic complex and the multifunctional nano-medicine, the mesoporous Fe_3O_4@PB can effectively load the drug cisplatin and exhibit temperature-sensitive drug release. Both the magnetic field and infrared laser can respond to the release of heat. The synthesized mesoporous eggshell Fe_3O_4@PB materials can effectively load drugs and kill cancer cells.
【學(xué)位授予單位】：華東師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TB33

【參考文獻(xiàn)】

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1 孫圣男;魏超;朱贊贊;侯仰龍;Subbu S Venkatraman;徐h醬，

本文編號：2231783