【摘要】：在過去的數(shù)十年中,催化劑已經(jīng)引起相當多的關注,在制藥和精細化工產(chǎn)業(yè)有很重要的的應用。催化劑已經(jīng)應用于許多合成反應。然而,大多數(shù)的均相催化劑由于許多實際因素是不適合在工業(yè)領域中應用。例如,均相催化劑不易從反應混合物中的簡單的分離和重復使用,這是有機合成中的成本控制的有效的方法。在制藥業(yè)中,它也必須除去所有金屬殘留痕跡,這經(jīng)常會干擾隨后的反應而污染最終產(chǎn)物。因此,發(fā)展一種可回收,重復使用的催化劑是十分必要的。我們制備了新型磁性納米催化劑Cu Fe O2,用檸檬酸-DMU低熔點混合物作為綠色溶劑。以苯甲醛、2-氨基吡啶和苯乙炔為原料合成咪唑并[1,2-а]吡啶類衍生物,并且得到不錯的產(chǎn)率。催化體系可以成功重復使用6次保持其催化活性。我們制備了納米材料負載銅[Ni Fe2O4-GM-Cu]催化劑,這種催化劑對于合成各種1,4-二取代-1,2,3-三唑表現(xiàn)出優(yōu)異的催化活性。反應由疊氮化鈉、非活化的末端炔烴和不同的疊氮化物前體,如環(huán)氧化物、芐基氯和芳基硼酸在水中室溫下進行。這種方法有許多突出優(yōu)勢,水作為反應媒介、廣泛的底物范圍和催化劑可以使用外加磁體進行有效的分離回收。3-硝基-2-苯基咪唑并[1,2-a]吡啶是一類重要的雜環(huán)化合物,這類化合物具有廣泛的生物活性。我們首先制備了一種磁性納米材料[Co Fe2O4@CNT-Cu]作為催化劑,在PEG400中以硝基甲烷、2-氨基吡啶和苯甲醛為原料得到相應的3-硝基-2-苯基咪唑并[1,2-a]吡啶類化合物,產(chǎn)率較高。磁性納米材料對于催化合成3-硝基-2-苯基咪唑并[1,2-a]吡啶類化合物具有較高的催化活性,并且磁性納米材料的諸多優(yōu)點如:制備簡單、便于與產(chǎn)物分離和可循環(huán)利用等,都使得磁性納米材料的廣泛應用于有機合成中成為可能。
[Abstract]:In the past decades, catalysts have attracted considerable attention and have important applications in pharmaceutical and fine chemical industries. Catalysts have been used in many synthetic reactions. However, most homogeneous catalysts are not suitable for industrial application due to many practical factors. For example, homogeneous catalysts are not easy to separate and reuse from the reaction mixture, which is an effective method of cost control in organic synthesis. In the pharmaceutical industry, it must also remove all traces of metal, which often interfere with subsequent reactions and contaminate the end product. Therefore, the development of a recyclable, reusable catalyst is very necessary. A new magnetic nanometer catalyst Cu Fe O 2 was prepared. The citric acid-DMU low melting point mixture was used as green solvent. Imidazo [1] pyridine derivatives were synthesized from benzaldehyde 2-aminopyridine and phenylacetylene, and a good yield was obtained. The catalytic system can be successfully reused for 6 times to maintain its catalytic activity. Nanomaterials supported on copper [Ni Fe2O4-GM-Cu] catalysts have been prepared. The catalysts exhibit excellent catalytic activity for the synthesis of various 1o 4- disubstituted -1o 2o 3- triazole. The reaction was carried out by sodium azide, non-activated terminal alkynes and different azide precursors, such as epoxides, benzyl chloride and aryl boric acid in water at room temperature. This method has many outstanding advantages. Water as a reaction medium, a wide range of substrates and catalysts can be used for effective separation and recovery of .3-nitro-2-phenylimidazo [1o2-a] pyridine as a class of important heterocyclic compounds. These compounds have a wide range of biological activities. In this paper, we first prepared a magnetic nano-material [Co Fe2O4@CNT-Cu] as catalyst, using nitromethane 2-aminopyridine and benzaldehyde as raw materials to obtain the corresponding 3-nitro-2-phenylimidazo [1o 2-a] pyridine compounds in high yield. Magnetic nanomaterials have high catalytic activity for the catalytic synthesis of 3-nitro-2-phenylimidazo [1t2-a] pyridine compounds. The magnetic nanomaterials have many advantages, such as simple preparation, easy separation and recycling, etc. All of these make it possible for magnetic nanomaterials to be widely used in organic synthesis.
【學位授予單位】：河北師范大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：O626.32;TB383.1

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