【摘要】：目的檢測0~5歲健康兒童血清抗苗勒氏管激素(AMH)及抑制素B(INHB)濃度,為建立正常參考范圍提供幫助。方法選擇來自上海市兒童醫(yī)院、深圳市兒童醫(yī)院、天津醫(yī)科大學總醫(yī)院、江西省兒童醫(yī)院及成都市婦女兒童中心醫(yī)院的健康體檢男童及女童各700名,共1400名。根據年齡分為7組:0~1個月;1~6個月;6個月至1歲;1~2歲;2~3歲;3~4歲;4~5歲,其中每組男童及女童各100名。采用酶聯(lián)免疫吸附法(ELISA)檢測血清AMH濃度(μg/L)及INHB濃度(ng/L)。結果 0~5歲健康男童血清AMH濃度在1~6個月達高峰210.70(55.37~439.45)μg/L,1~5歲維持平穩(wěn)低水平147.10(17.69~321.88)ng/L;女童血清AMH濃度在1~6個月也出現小高峰1.77(0.06~7.68)ng/L,2~5歲趨于平穩(wěn)為1.98(0.19~7.31)ng/L。男童血清INHB濃度在1~6個月達高峰274.23(0.00~602.34)ng/L,女童1~6個月出現小高峰為36.83(0.00~226.32)ng/L。結論提供了多中心及大樣本0~5歲健康兒童血清AMH及INHB值的濃度范圍,并發(fā)現1~6個月年齡段出現濃度高峰。
[Abstract]:Objective to detect the serum levels of anti-Muller's tube hormone (AMH) and inhibin B (INHB) in healthy children aged 0 to 5 years old, and to provide help for the establishment of normal reference range. Methods A total of 1400 boys and girls from Shanghai Children's Hospital, Shenzhen Children's Hospital, Tianjin Medical University General Hospital, Jiangxi Provincial Children's Hospital and Chengdu Women's and Children's Center Hospital were selected. According to the age, they were divided into 7 groups: 0 鈮，

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