【摘要】：目的:探索碳青霉烯類抗菌藥物對(duì)臨床分離的100株大腸埃希菌、肺炎克雷伯菌β-內(nèi)酰胺酶表型和銅綠假單胞菌、鮑曼不動(dòng)桿菌的防突變濃度(MPC)。方法:采用瓊脂稀釋法測(cè)定碳青霉烯類(亞胺培南、美洛培南、厄他培南和多利培南)對(duì)臨床分離的革蘭陰性耐藥菌株的最低抑菌濃度(MIC)及MPC并計(jì)算MPC/MIC比值。采用WHONET5.6及SPASS13.0進(jìn)行分析。結(jié)果:腸桿菌科細(xì)菌和鮑曼不動(dòng)桿菌的MPC/MIC比值為2~4,銅綠假單胞菌為4-≥16。β-內(nèi)酰胺酶陽性的肺炎克雷伯菌、大腸埃希菌MPC/MIC比值高于β-內(nèi)酰胺酶陰性菌株(4至16μg·mL-1)。結(jié)論:基于MPC的碳青霉烯類抗菌藥物可以通過MPC/MIC比值調(diào)整給藥劑量,降低耐藥菌株的總體數(shù)量和感染負(fù)荷,抑制耐藥菌突變體的選擇性富集擴(kuò)增。
[Abstract]:Objective: to investigate the effects of carbapenems on 尾-lactamase phenotypes of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in 100 clinical isolates of Escherichia coli and Acinetobacter baumannii (MPC). Methods: the minimal inhibitory concentrations (MIC) and MPC of carbapenems (imipenem, meropenem, etapenem and dolipenem) against clinically isolated Gram-negative drug-resistant strains were determined by Agar dilution method. The MPC/MIC ratio was calculated. WHONET5.6 and SPASS13.0 were used for analysis. Results: the MPC/MIC ratio of Enterobacteriaceae to Acinetobacter baumannii was 2? 4, Pseudomonas aeruginosa was 4-鈮，

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