【摘要】：條件性疼痛調節(jié)(CPM)是一種內源性疼痛調節(jié),指身體某一部位的持續(xù)性疼痛可以抑制施于身體另一部位的傷害性刺激所引起的疼痛感知.本文首先概述了與CPM相關的神經(jīng)生理、生化機制,并介紹了測量個體CPM效率的傳統(tǒng)心理物理學方法,總結了基于腦電和功能磁共振等神經(jīng)成像技術評估CPM效率的神經(jīng)生理指標,并提出應綜合心理物理學和神經(jīng)生理學方法評估個體CPM功能.然后,從人口統(tǒng)計學、生理學和心理學幾個方面詳細探討了影響個體CPM功能的復雜因素,從而提示大家應綜合考慮影響個體CPM效率的因素.最后,本文總結了CPM相關的臨床應用,包括慢性疼痛預測與評估、鎮(zhèn)痛藥物劑量預測以及個體健康質量評估等.本文既能加深對人類疼痛調節(jié)功能潛在機制的理解,又能為臨床上慢性疼痛疾病的預測和評估提供參考依據(jù).
[Abstract]:Conditioned pain regulation (CPM) is an endogenous pain regulation, which indicates that persistent pain in one part of the body can inhibit pain perception caused by nociceptive stimuli applied to another part of the body. In this paper, the neurophysiological and biochemical mechanisms related to CPM are summarized, and the traditional psychophysical methods for measuring the efficiency of individual CPM are introduced, and the neurophysiological indexes for evaluating the efficiency of CPM based on EEG and functional magnetic resonance imaging techniques are summarized. It is suggested that the individual CPM function should be evaluated by the methods of psychophysics and neurophysiology. Then, from the aspects of demography, physiology and psychology, this paper discusses in detail the complex factors that affect the function of individual CPM, which suggests that we should consider the factors that affect the efficiency of individual CPM. Finally, the clinical application of CPM was summarized, including the prediction and evaluation of chronic pain, the dose prediction of analgesic drugs and the evaluation of individual health quality. This article can not only deepen the understanding of the potential mechanism of human pain regulation function, but also provide a reference for clinical prediction and evaluation of chronic pain diseases.
【作者單位】： 西南大學心理學部認知與人格教育部重點實驗室;遵義師范學院教育科學學院;
【基金】：國家自然科學基金(31200856,31471082,31500921)資助
【分類號】：R402
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本文編號：2190965