本文關(guān)鍵詞： 成纖維細胞生長因子 持續(xù)性非臥床腹膜透析 血管鈣化　出處：《中國實用內(nèi)科雜志》2016年08期 　論文類型：期刊論文

【摘要】：目的探討成纖維細胞生長因子23(fibroblast growth factor-23,FGF23)與持續(xù)性非臥床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者腹主動脈鈣化之間的相關(guān)性。方法收集2013-07-01—2014-03-01在中國醫(yī)科大學(xué)附屬第一醫(yī)院及遼寧省人民醫(yī)院接受腹膜透析治療時間3個月,病情平穩(wěn)的CAPD患者58例的臨床資料及血生化指標,應(yīng)用酶聯(lián)免疫吸附試驗(ELISA)測定血清中FGF23水平,腹部側(cè)位平片測定腹主動脈鈣化(abdominal aortic calcification,AAC)評分情況,采用Pearson相關(guān)性分析方法分析FGF23與AAC評分之間的相關(guān)性,采用多元線性回歸分析FGF23濃度、臨床生化指標和AAC之間的關(guān)系。以腹主動脈重度鈣化(AAC≥16賦值為1)作為因變量,應(yīng)用Logistic回歸分析方法分析CAPD患者發(fā)生腹主動脈重度鈣化的危險因素。結(jié)果 58例CAPD患者中有50例發(fā)生腹主動脈鈣化,鈣化發(fā)生率為86.2%。血清FGF23的濃度為(157.89±46.23)ng/L。FGF23與AAC評分呈正相關(guān)(r=0.403,P0.05),與骨特異性堿性磷酸酶(bone-specific alkaline phosphatase,BAP)呈正相關(guān)(r=0.71,P0.05),與血磷、全段甲狀旁腺素(iPTH)、血鈣、25-羥維生素D無顯著相關(guān)性。多元線性回歸分析顯示,FGF23與AAC無相關(guān)性(r=-0.47,P=0.96)。Logistic回歸分析顯示,血清FGF23升高是CAPD患者發(fā)生腹主動脈重度鈣化的危險因素(β=0.069,OR=1.071,P0.05)。結(jié)論血清FGF23濃度升高是CAPD患者發(fā)生腹主動脈重度鈣化的危險因素。
[Abstract]:Objective to investigate the relationship between fibroblast growth factor-23 (FGF23) and calcification of abdominal aorta in patients with continuous ambulatory peritoneal dialysism (CAPDD). Methods 2013-07-01-2014-03-01 was collected in the first affiliated Hospital of China Medical University and people of Liaoning Province. The hospital received peritoneal dialysis for 3 months. The clinical data and blood biochemical indexes of 58 patients with stable CAPD were measured by Elisa. The serum FGF23 level was measured by Elisa, and the abdominal aortic calcification aortic calcification AAC score was measured by abdominal lateral plain film. The correlation between FGF23 and AAC score was analyzed by Pearson correlation analysis, and the relationship between FGF23 concentration, clinical biochemical index and AAC was analyzed by multiple linear regression analysis. The AAC 鈮，

本文編號：1525829